Profiling heterogeneity in Human derived IPSC-neurons (2020-05-18)
The impact of genetic variants on molecular pathways that give rise to neurodegenerative diseases such as Alzheimer's and Parkinson's is best elucidated in the appropriate cell types and molecular contexts. Existing studies have focused on bulk profiling of mixed cell types, but have ignored assaying genetic effects across development and cell differentiation. At the core of this proposal is the idea to use single-cell assays to study genetic effects during differentiation of dopaminergic and cortical neurons to identify the sequence of molecular events from variants to healthy and diseased cell states in a cell-specific manner. 1) This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see http://www.sanger.ac.uk/datasharing/ . This dataset contains all the data available for this study on 2020-05-18.
- 42 samples
- DAC: EGAC00001000205
- Technology: Illumina HiSeq 4000
Wellcome Trust Sanger Institute Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001002885 | Transcriptome Analysis |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00003942976 | cram | 5.5 GB | ||
| EGAF00003942977 | cram | 4.1 GB | ||
| EGAF00003942978 | cram | 5.4 GB | ||
| EGAF00003942979 | cram | 7.2 GB | ||
| EGAF00003942980 | cram | 6.4 GB | ||
| EGAF00003942981 | cram | 4.5 GB | ||
| EGAF00003942982 | cram | 7.0 GB | ||
| EGAF00003942983 | cram | 3.9 GB | ||
| EGAF00003942984 | cram | 7.3 GB | ||
| EGAF00003942985 | cram | 4.0 GB | ||
| EGAF00003942986 | cram | 7.3 GB | ||
| EGAF00003942987 | cram | 3.9 GB | ||
| EGAF00003942988 | cram | 5.7 GB | ||
| EGAF00003942989 | cram | 3.2 GB | ||
| EGAF00003942990 | cram | 5.2 GB | ||
| EGAF00003942991 | cram | 6.7 GB | ||
| EGAF00003942992 | cram | 7.1 GB | ||
| EGAF00003942993 | cram | 5.0 GB | ||
| EGAF00003942994 | cram | 4.6 GB | ||
| EGAF00003942995 | cram | 4.9 GB | ||
| EGAF00003942996 | cram | 6.5 GB | ||
| EGAF00003942997 | cram | 3.2 GB | ||
| EGAF00003942998 | cram | 4.9 GB | ||
| EGAF00003942999 | cram | 4.8 GB | ||
| EGAF00003943000 | cram | 5.9 GB | ||
| EGAF00003943001 | cram | 6.4 GB | ||
| EGAF00003943002 | cram | 6.4 GB | ||
| EGAF00003943003 | cram | 3.5 GB | ||
| EGAF00003943004 | cram | 4.2 GB | ||
| EGAF00003943005 | cram | 7.7 GB | ||
| EGAF00003943006 | cram | 4.7 GB | ||
| EGAF00003943007 | cram | 4.9 GB | ||
| EGAF00003943008 | cram | 4.5 GB | ||
| EGAF00003943009 | cram | 5.9 GB | ||
| EGAF00003943010 | cram | 6.4 GB | ||
| EGAF00003943011 | cram | 4.3 GB | ||
| EGAF00003943012 | cram | 6.2 GB | ||
| EGAF00003943013 | cram | 4.8 GB | ||
| EGAF00003943014 | cram | 4.7 GB | ||
| EGAF00003943015 | cram | 5.1 GB | ||
| EGAF00003943016 | cram | 5.0 GB | ||
| EGAF00003943017 | cram | 4.9 GB | ||
| EGAF00003943018 | cram | 6.1 GB | ||
| EGAF00003943019 | cram | 4.4 GB | ||
| EGAF00003943020 | cram | 2.8 GB | ||
| EGAF00003943021 | cram | 6.7 GB | ||
| EGAF00003943022 | cram | 5.2 GB | ||
| EGAF00003943023 | cram | 6.4 GB | ||
| EGAF00003943024 | cram | 5.1 GB | ||
| EGAF00003943025 | cram | 7.5 GB | ||
| EGAF00003943026 | cram | 5.0 GB | ||
| EGAF00003943027 | cram | 3.7 GB | ||
| EGAF00003943028 | cram | 4.1 GB | ||
| EGAF00003943029 | cram | 4.2 GB | ||
| EGAF00003943030 | cram | 7.0 GB | ||
| EGAF00003943031 | cram | 4.9 GB | ||
| EGAF00003943032 | cram | 5.4 GB | ||
| EGAF00003943033 | cram | 970.0 MB | ||
| EGAF00003943034 | cram | 6.6 GB | ||
| EGAF00003943035 | cram | 4.8 GB | ||
| EGAF00003943036 | cram | 4.1 GB | ||
| EGAF00003943037 | cram | 5.0 GB | ||
| EGAF00003943038 | cram | 5.2 GB | ||
| EGAF00003943039 | cram | 3.1 GB | ||
| EGAF00003943040 | cram | 5.4 GB | ||
| EGAF00003943041 | cram | 7.1 GB | ||
| EGAF00003943042 | cram | 6.3 GB | ||
| EGAF00003943043 | cram | 3.9 GB | ||
| EGAF00003943044 | cram | 7.2 GB | ||
| EGAF00003943045 | cram | 5.0 GB | ||
| EGAF00003943046 | cram | 4.5 GB | ||
| EGAF00003943047 | cram | 4.6 GB | ||
| EGAF00003943048 | cram | 5.3 GB | ||
| EGAF00003943049 | cram | 6.0 GB | ||
| EGAF00003943050 | cram | 6.1 GB | ||
| EGAF00003943051 | cram | 6.3 GB | ||
| EGAF00003943052 | cram | 4.7 GB | ||
| EGAF00003943053 | cram | 4.7 GB | ||
| EGAF00003943054 | cram | 7.8 GB | ||
| EGAF00003943055 | cram | 6.7 GB | ||
| EGAF00003943056 | cram | 5.5 GB | ||
| EGAF00003943057 | cram | 4.0 GB | ||
| EGAF00003943058 | cram | 7.2 GB | ||
| EGAF00003943059 | cram | 6.8 GB | ||
| EGAF00003943060 | cram | 5.2 GB | ||
| EGAF00003943061 | cram | 4.5 GB | ||
| EGAF00003943062 | cram | 7.8 GB | ||
| EGAF00003943063 | cram | 5.7 GB | ||
| EGAF00003943064 | cram | 6.9 GB | ||
| EGAF00003943065 | cram | 1.8 GB | ||
| EGAF00003943066 | cram | 8.4 GB | ||
| EGAF00003943067 | cram | 6.3 GB | ||
| EGAF00003943068 | cram | 5.3 GB | ||
| EGAF00003943069 | cram | 6.5 GB | ||
| EGAF00003943070 | cram | 6.7 GB | ||
| EGAF00003943071 | cram | 4.5 GB | ||
| EGAF00003943072 | cram | 5.3 GB | ||
| EGAF00003943073 | cram | 7.1 GB | ||
| EGAF00003943074 | cram | 6.6 GB | ||
| EGAF00003943075 | cram | 5.5 GB | ||
| EGAF00003943076 | cram | 5.7 GB | ||
| EGAF00003943077 | cram | 4.2 GB | ||
| EGAF00003943078 | cram | 5.3 GB | ||
| EGAF00003943079 | cram | 6.4 GB | ||
| EGAF00003943080 | cram | 7.1 GB | ||
| EGAF00003943081 | cram | 4.7 GB | ||
| EGAF00003943082 | cram | 7.5 GB | ||
| EGAF00003943083 | cram | 5.4 GB | ||
| EGAF00003943084 | cram | 5.3 GB | ||
| EGAF00003943085 | cram | 6.8 GB | ||
| EGAF00003943086 | cram | 5.3 GB | ||
| EGAF00003943087 | cram | 5.1 GB | ||
| EGAF00003943088 | cram | 7.1 GB | ||
| EGAF00003943089 | cram | 6.3 GB | ||
| EGAF00003943090 | cram | 3.5 GB | ||
| EGAF00003943091 | cram | 5.3 GB | ||
| EGAF00003943092 | cram | 5.9 GB | ||
| EGAF00003943093 | cram | 4.6 GB | ||
| EGAF00003943094 | cram | 7.6 GB | ||
| EGAF00003943095 | cram | 4.4 GB | ||
| EGAF00003943096 | cram | 5.0 GB | ||
| EGAF00003943097 | cram | 4.8 GB | ||
| EGAF00003943098 | cram | 5.7 GB | ||
| EGAF00003943099 | cram | 6.8 GB | ||
| EGAF00003943100 | cram | 5.8 GB | ||
| EGAF00003943101 | cram | 7.1 GB | ||
| EGAF00003943102 | cram | 7.2 GB | ||
| EGAF00003943103 | cram | 3.2 GB | ||
| EGAF00003943104 | cram | 7.3 GB | ||
| EGAF00003943105 | cram | 69.8 MB | ||
| EGAF00003943106 | cram | 7.5 GB | ||
| EGAF00003943107 | cram | 9.5 GB | ||
| EGAF00003943108 | cram | 7.4 GB | ||
| EGAF00003943109 | cram | 5.8 GB | ||
| EGAF00003943110 | cram | 4.1 GB | ||
| EGAF00003943111 | cram | 6.1 GB | ||
| EGAF00003943112 | cram | 7.3 GB | ||
| EGAF00003943113 | cram | 5.2 GB | ||
| EGAF00003943114 | cram | 5.0 GB | ||
| EGAF00003943115 | cram | 4.8 GB | ||
| EGAF00003943116 | cram | 5.1 GB | ||
| EGAF00003943117 | cram | 5.6 GB | ||
| EGAF00003943118 | cram | 6.2 GB | ||
| EGAF00003943119 | cram | 5.7 GB | ||
| EGAF00003943120 | cram | 6.1 GB | ||
| EGAF00003943121 | cram | 5.5 GB | ||
| EGAF00003943122 | cram | 7.3 GB | ||
| EGAF00003943123 | cram | 3.8 GB | ||
| EGAF00003943124 | cram | 7.2 GB | ||
| EGAF00003943125 | cram | 4.8 GB | ||
| EGAF00003943126 | cram | 6.6 GB | ||
| EGAF00003943127 | cram | 3.8 GB | ||
| EGAF00003943128 | cram | 5.9 GB | ||
| EGAF00003943129 | cram | 5.5 GB | ||
| EGAF00003943130 | cram | 6.5 GB | ||
| EGAF00003943131 | cram | 2.3 GB | ||
| EGAF00003943132 | cram | 7.4 GB | ||
| EGAF00003943133 | cram | 4.7 GB | ||
| EGAF00003943134 | cram | 6.0 GB | ||
| EGAF00003943135 | cram | 1.7 GB | ||
| EGAF00003943136 | cram | 5.6 GB | ||
| EGAF00003943137 | cram | 4.5 GB | ||
| EGAF00003943138 | cram | 7.1 GB | ||
| EGAF00003943139 | cram | 2.6 GB | ||
| EGAF00003943140 | cram | 6.4 GB | ||
| EGAF00003943141 | cram | 4.2 GB | ||
| EGAF00003943142 | cram | 5.4 GB | ||
| EGAF00003943143 | cram | 3.8 GB | ||
| 168 Files (918.0 GB) | ||||