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Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma -- CA209-025

Immune checkpoint inhibitors targeting the PD-1 pathway have transformed the management of many advanced malignancies, including clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors collected from advanced ccRCC patients enrolled in prospective clinical trials of treatment with PD-1 blockade (or mTOR inhibition as control arm) by whole-exome and RNA-sequencing, integrated with immunofluorescence analysis, to define the somatic alteration landscape of late-stage ccRCC and to uncover the immunogenomic determinants of therapeutic response. While conventional genomic markers (tumor mutation burden, neoantigen load) and degree of CD8+ T cell infiltration were not associated with clinical response, we discovered numerous chromosomal alterations in advanced ccRCC associated with response or resistance to PD-1 blockade. These advanced tumors were highly CD8+ T cell infiltrated, with only 22% and 5% with an immune desert and immune excluded phenotype, respectively. Our analysis revealed that CD8+ infiltrated tumors are depleted of favorable PBRM1 mutations and are enriched for unfavorable chromosomal losses of 9p21.3 when compared to non-infiltrated tumors. These data demonstrate how the interplay of somatic alterations and immunophenotypes impacts therapeutic efficacy.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00003476797 fastq.gz 8.1 GB
EGAF00003476798 fastq.gz 8.2 GB
EGAF00003476799 fastq.gz 9.1 GB
EGAF00003476800 fastq.gz 9.4 GB
EGAF00003476801 fastq.gz 6.4 GB
EGAF00003476802 fastq.gz 6.4 GB
EGAF00003476803 fastq.gz 6.3 GB
EGAF00003476804 fastq.gz 6.7 GB
EGAF00003476805 fastq.gz 6.3 GB
EGAF00003476806 fastq.gz 6.6 GB
EGAF00003476807 fastq.gz 5.2 GB
EGAF00003476808 fastq.gz 5.2 GB
EGAF00003476809 fastq.gz 5.5 GB
EGAF00003476810 fastq.gz 5.6 GB
EGAF00003476811 fastq.gz 5.9 GB
EGAF00003476812 fastq.gz 6.1 GB
EGAF00003476813 fastq.gz 5.7 GB
EGAF00003476814 fastq.gz 5.6 GB
EGAF00003476815 fastq.gz 6.0 GB
EGAF00003476816 fastq.gz 6.0 GB
EGAF00003476817 fastq.gz 6.5 GB
EGAF00003476818 fastq.gz 6.7 GB
EGAF00003476819 fastq.gz 8.8 GB
EGAF00003476820 fastq.gz 9.4 GB
EGAF00003476821 fastq.gz 7.6 GB
EGAF00003476822 fastq.gz 7.6 GB
EGAF00003476823 fastq.gz 6.7 GB
EGAF00003476824 fastq.gz 6.8 GB
EGAF00003476825 fastq.gz 6.5 GB
EGAF00003476826 fastq.gz 7.0 GB
EGAF00003476827 fastq.gz 6.6 GB
EGAF00003476828 fastq.gz 6.4 GB
EGAF00003476829 fastq.gz 6.7 GB
EGAF00003476830 fastq.gz 6.8 GB
EGAF00003476831 fastq.gz 6.4 GB
EGAF00003476832 fastq.gz 6.5 GB
EGAF00003476833 fastq.gz 6.3 GB
EGAF00003476834 fastq.gz 6.5 GB
EGAF00003476835 fastq.gz 6.9 GB
EGAF00003476836 fastq.gz 7.1 GB
EGAF00003476837 fastq.gz 5.6 GB
EGAF00003476838 fastq.gz 5.8 GB
EGAF00003476839 fastq.gz 7.4 GB
EGAF00003476840 fastq.gz 7.8 GB
EGAF00003476841 fastq.gz 6.1 GB
EGAF00003476842 fastq.gz 6.4 GB
EGAF00003476843 fastq.gz 7.2 GB
EGAF00003476844 fastq.gz 7.6 GB
EGAF00003476845 fastq.gz 5.6 GB
EGAF00003476846 fastq.gz 5.8 GB
EGAF00003476847 fastq.gz 5.8 GB
EGAF00003476848 fastq.gz 5.9 GB
EGAF00003476849 fastq.gz 7.2 GB
EGAF00003476850 fastq.gz 7.4 GB
EGAF00003476851 fastq.gz 6.9 GB
EGAF00003476852 fastq.gz 6.9 GB
EGAF00003476853 fastq.gz 5.7 GB
EGAF00003476854 fastq.gz 5.9 GB
EGAF00003476855 fastq.gz 5.5 GB
EGAF00003476856 fastq.gz 5.8 GB
EGAF00003476857 fastq.gz 7.1 GB
EGAF00003476858 fastq.gz 7.1 GB
EGAF00003476859 fastq.gz 5.8 GB
EGAF00003476860 fastq.gz 5.9 GB
EGAF00003476861 fastq.gz 8.2 GB
EGAF00003476862 fastq.gz 8.3 GB
EGAF00003476863 fastq.gz 7.3 GB
EGAF00003476864 fastq.gz 7.4 GB
EGAF00003476865 fastq.gz 5.9 GB
EGAF00003476866 fastq.gz 6.1 GB
EGAF00003476867 fastq.gz 4.9 GB
EGAF00003476868 fastq.gz 4.9 GB
EGAF00003476869 fastq.gz 7.6 GB
EGAF00003476870 fastq.gz 7.6 GB
EGAF00003476871 fastq.gz 6.2 GB
EGAF00003476872 fastq.gz 6.3 GB
EGAF00003476873 fastq.gz 5.9 GB
EGAF00003476874 fastq.gz 6.0 GB
EGAF00003476875 fastq.gz 5.6 GB
EGAF00003476876 fastq.gz 5.8 GB
EGAF00003476877 fastq.gz 5.8 GB
EGAF00003476878 fastq.gz 6.0 GB
EGAF00003476879 fastq.gz 5.6 GB
EGAF00003476880 fastq.gz 5.6 GB
EGAF00003476881 fastq.gz 6.3 GB
EGAF00003476882 fastq.gz 6.4 GB
EGAF00003476883 fastq.gz 7.0 GB
EGAF00003476884 fastq.gz 7.1 GB
EGAF00003476885 fastq.gz 7.7 GB
EGAF00003476886 fastq.gz 7.7 GB
EGAF00003476887 fastq.gz 8.2 GB
EGAF00003476888 fastq.gz 8.2 GB
EGAF00003476889 fastq.gz 6.3 GB
EGAF00003476890 fastq.gz 6.4 GB
EGAF00003476891 fastq.gz 6.3 GB
EGAF00003476892 fastq.gz 6.3 GB
EGAF00003476893 fastq.gz 5.6 GB
EGAF00003476894 fastq.gz 5.8 GB
EGAF00003476895 fastq.gz 6.6 GB
EGAF00003476896 fastq.gz 6.6 GB
EGAF00003476897 fastq.gz 6.5 GB
EGAF00003476898 fastq.gz 6.9 GB
EGAF00003476899 fastq.gz 6.6 GB
EGAF00003476900 fastq.gz 6.6 GB
EGAF00003476901 fastq.gz 6.3 GB
EGAF00003476902 fastq.gz 6.2 GB
EGAF00003476903 fastq.gz 8.1 GB
EGAF00003476904 fastq.gz 8.1 GB
EGAF00003476905 fastq.gz 6.7 GB
EGAF00003476906 fastq.gz 7.0 GB
EGAF00003476907 fastq.gz 6.1 GB
EGAF00003476908 fastq.gz 6.3 GB
EGAF00003476909 fastq.gz 5.5 GB
EGAF00003476910 fastq.gz 5.6 GB
EGAF00003476911 fastq.gz 6.0 GB
EGAF00003476912 fastq.gz 6.1 GB
EGAF00003476913 fastq.gz 7.7 GB
EGAF00003476914 fastq.gz 8.0 GB
EGAF00003476915 fastq.gz 5.7 GB
EGAF00003476916 fastq.gz 5.6 GB
EGAF00003476917 fastq.gz 6.8 GB
EGAF00003476918 fastq.gz 6.7 GB
EGAF00003476919 fastq.gz 6.7 GB
EGAF00003476920 fastq.gz 6.9 GB
EGAF00003476921 fastq.gz 8.5 GB
EGAF00003476922 fastq.gz 8.6 GB
EGAF00003476923 fastq.gz 6.9 GB
EGAF00003476924 fastq.gz 7.0 GB
EGAF00003476925 fastq.gz 10.4 GB
EGAF00003476926 fastq.gz 10.5 GB
EGAF00003476927 fastq.gz 8.1 GB
EGAF00003476928 fastq.gz 8.2 GB
EGAF00003476929 fastq.gz 6.2 GB
EGAF00003476930 fastq.gz 6.4 GB
EGAF00003476931 fastq.gz 6.2 GB
EGAF00003476932 fastq.gz 6.5 GB
EGAF00003476933 fastq.gz 7.3 GB
EGAF00003476934 fastq.gz 7.6 GB
EGAF00003476935 fastq.gz 5.9 GB
EGAF00003476936 fastq.gz 6.2 GB
EGAF00003476937 fastq.gz 6.0 GB
EGAF00003476938 fastq.gz 6.1 GB
EGAF00003476939 fastq.gz 8.5 GB
EGAF00003476940 fastq.gz 8.5 GB
EGAF00003476941 fastq.gz 8.2 GB
EGAF00003476942 fastq.gz 8.3 GB
EGAF00003476943 fastq.gz 5.7 GB
EGAF00003476944 fastq.gz 5.8 GB
EGAF00003476945 fastq.gz 6.0 GB
EGAF00003476946 fastq.gz 6.2 GB
EGAF00003476947 fastq.gz 6.2 GB
EGAF00003476948 fastq.gz 6.4 GB
EGAF00003476949 fastq.gz 7.0 GB
EGAF00003476950 fastq.gz 7.4 GB
EGAF00003476951 fastq.gz 5.6 GB
EGAF00003476952 fastq.gz 5.7 GB
EGAF00003476953 fastq.gz 8.1 GB
EGAF00003476954 fastq.gz 8.0 GB
EGAF00003476955 fastq.gz 5.6 GB
EGAF00003476956 fastq.gz 5.6 GB
EGAF00003476957 fastq.gz 6.2 GB
EGAF00003476958 fastq.gz 6.2 GB
EGAF00003476959 fastq.gz 5.3 GB
EGAF00003476960 fastq.gz 5.5 GB
EGAF00003476961 fastq.gz 6.9 GB
EGAF00003476962 fastq.gz 6.3 GB
EGAF00003476963 fastq.gz 5.3 GB
EGAF00003476964 fastq.gz 5.5 GB
EGAF00003476965 fastq.gz 6.2 GB
EGAF00003476966 fastq.gz 6.4 GB
EGAF00003476967 fastq.gz 8.6 GB
EGAF00003476968 fastq.gz 8.6 GB
EGAF00003476969 fastq.gz 7.6 GB
EGAF00003476970 fastq.gz 7.9 GB
EGAF00003476971 fastq.gz 5.9 GB
EGAF00003476972 fastq.gz 6.4 GB
EGAF00003476973 fastq.gz 5.6 GB
EGAF00003476974 fastq.gz 5.5 GB
EGAF00003476975 fastq.gz 7.8 GB
EGAF00003476976 fastq.gz 8.2 GB
EGAF00003476977 fastq.gz 6.4 GB
EGAF00003476978 fastq.gz 6.6 GB
EGAF00003476979 fastq.gz 8.6 GB
EGAF00003476980 fastq.gz 8.6 GB
EGAF00003476981 fastq.gz 6.6 GB
EGAF00003476982 fastq.gz 6.9 GB
EGAF00003476983 fastq.gz 6.0 GB
EGAF00003476984 fastq.gz 5.8 GB
EGAF00003476985 fastq.gz 6.1 GB
EGAF00003476986 fastq.gz 6.1 GB
EGAF00003476987 fastq.gz 5.8 GB
EGAF00003476988 fastq.gz 5.9 GB
EGAF00003476989 fastq.gz 5.6 GB
EGAF00003476990 fastq.gz 5.8 GB
EGAF00003476991 fastq.gz 6.4 GB
EGAF00003476992 fastq.gz 6.7 GB
EGAF00003476993 fastq.gz 6.3 GB
EGAF00003476994 fastq.gz 6.5 GB
EGAF00003476995 fastq.gz 4.5 GB
EGAF00003476996 fastq.gz 4.6 GB
EGAF00003476997 fastq.gz 4.1 GB
EGAF00003476998 fastq.gz 4.2 GB
EGAF00003476999 fastq.gz 4.5 GB
EGAF00003477000 fastq.gz 4.7 GB
EGAF00003477001 fastq.gz 3.2 GB
EGAF00003477002 fastq.gz 3.3 GB
EGAF00003477003 fastq.gz 4.0 GB
EGAF00003477004 fastq.gz 4.1 GB
EGAF00003477005 fastq.gz 4.0 GB
EGAF00003477006 fastq.gz 4.0 GB
EGAF00003477007 fastq.gz 4.8 GB
EGAF00003477008 fastq.gz 4.8 GB
EGAF00003477009 fastq.gz 4.0 GB
EGAF00003477010 fastq.gz 4.1 GB
EGAF00003477011 fastq.gz 4.6 GB
EGAF00003477012 fastq.gz 4.8 GB
EGAF00003477013 fastq.gz 4.5 GB
EGAF00003477014 fastq.gz 4.7 GB
EGAF00003477015 fastq.gz 4.4 GB
EGAF00003477016 fastq.gz 4.5 GB
EGAF00003477017 fastq.gz 4.2 GB
EGAF00003477018 fastq.gz 4.2 GB
EGAF00003477019 fastq.gz 4.2 GB
EGAF00003477020 fastq.gz 4.3 GB
EGAF00003477021 fastq.gz 4.5 GB
EGAF00003477022 fastq.gz 4.8 GB
EGAF00003477023 fastq.gz 4.3 GB
EGAF00003477024 fastq.gz 4.4 GB
EGAF00003477025 fastq.gz 4.6 GB
EGAF00003477026 fastq.gz 4.7 GB
EGAF00003477027 fastq.gz 4.7 GB
EGAF00003477028 fastq.gz 4.9 GB
EGAF00003477029 fastq.gz 4.1 GB
EGAF00003477030 fastq.gz 4.3 GB
EGAF00003477031 fastq.gz 4.5 GB
EGAF00003477032 fastq.gz 4.7 GB
EGAF00003477033 fastq.gz 4.9 GB
EGAF00003477034 fastq.gz 5.1 GB
EGAF00003477035 fastq.gz 3.9 GB
EGAF00003477036 fastq.gz 4.0 GB
EGAF00003477037 fastq.gz 4.2 GB
EGAF00003477038 fastq.gz 4.1 GB
EGAF00003477039 fastq.gz 4.2 GB
EGAF00003477040 fastq.gz 4.3 GB
EGAF00003477041 fastq.gz 3.8 GB
EGAF00003477042 fastq.gz 3.9 GB
EGAF00003477043 fastq.gz 4.5 GB
EGAF00003477044 fastq.gz 4.8 GB
EGAF00003477045 fastq.gz 4.0 GB
EGAF00003477046 fastq.gz 4.2 GB
EGAF00003477047 fastq.gz 4.1 GB
EGAF00003477048 fastq.gz 4.3 GB
EGAF00003477049 fastq.gz 4.1 GB
EGAF00003477050 fastq.gz 4.3 GB
EGAF00003477051 fastq.gz 4.4 GB
EGAF00003477052 fastq.gz 4.7 GB
EGAF00003477053 fastq.gz 4.7 GB
EGAF00003477054 fastq.gz 4.8 GB
EGAF00003477055 fastq.gz 4.2 GB
EGAF00003477056 fastq.gz 4.5 GB
EGAF00003477057 fastq.gz 4.3 GB
EGAF00003477058 fastq.gz 4.4 GB
EGAF00003477059 fastq.gz 4.6 GB
EGAF00003477060 fastq.gz 4.7 GB
EGAF00003477061 fastq.gz 4.7 GB
EGAF00003477062 fastq.gz 4.9 GB
EGAF00003477063 fastq.gz 4.3 GB
EGAF00003477064 fastq.gz 4.4 GB
EGAF00003477065 fastq.gz 3.6 GB
EGAF00003477066 fastq.gz 3.6 GB
EGAF00003477067 fastq.gz 4.6 GB
EGAF00003477068 fastq.gz 4.8 GB
EGAF00003477069 fastq.gz 4.6 GB
EGAF00003477070 fastq.gz 4.7 GB
EGAF00003477071 fastq.gz 3.9 GB
EGAF00003477072 fastq.gz 4.1 GB
EGAF00003477073 fastq.gz 4.5 GB
EGAF00003477074 fastq.gz 4.6 GB
EGAF00003477075 fastq.gz 4.4 GB
EGAF00003477076 fastq.gz 4.4 GB
EGAF00003477077 fastq.gz 3.8 GB
EGAF00003477078 fastq.gz 3.9 GB
EGAF00003477079 fastq.gz 4.3 GB
EGAF00003477080 fastq.gz 4.5 GB
EGAF00003477081 fastq.gz 4.6 GB
EGAF00003477082 fastq.gz 4.8 GB
EGAF00003477083 fastq.gz 4.7 GB
EGAF00003477084 fastq.gz 4.7 GB
EGAF00003477085 fastq.gz 3.7 GB
EGAF00003477086 fastq.gz 3.8 GB
EGAF00003477087 fastq.gz 4.6 GB
EGAF00003477088 fastq.gz 4.7 GB
EGAF00003477089 fastq.gz 4.5 GB
EGAF00003477090 fastq.gz 4.7 GB
EGAF00003477091 fastq.gz 4.6 GB
EGAF00003477092 fastq.gz 4.8 GB
EGAF00003477093 fastq.gz 4.3 GB
EGAF00003477094 fastq.gz 4.6 GB
EGAF00003477095 fastq.gz 4.7 GB
EGAF00003477096 fastq.gz 4.9 GB
EGAF00003477097 fastq.gz 4.2 GB
EGAF00003477098 fastq.gz 4.2 GB
EGAF00003477099 fastq.gz 5.2 GB
EGAF00003477100 fastq.gz 5.5 GB
EGAF00003477101 fastq.gz 4.2 GB
EGAF00003477102 fastq.gz 4.2 GB
EGAF00003477103 fastq.gz 4.4 GB
EGAF00003477104 fastq.gz 4.5 GB
EGAF00003477105 fastq.gz 3.9 GB
EGAF00003477106 fastq.gz 3.9 GB
EGAF00003477107 fastq.gz 4.2 GB
EGAF00003477108 fastq.gz 4.3 GB
EGAF00003477109 fastq.gz 4.3 GB
EGAF00003477110 fastq.gz 4.5 GB
EGAF00003477111 fastq.gz 4.3 GB
EGAF00003477112 fastq.gz 4.4 GB
EGAF00003477113 fastq.gz 4.3 GB
EGAF00003477114 fastq.gz 4.2 GB
EGAF00003477115 fastq.gz 4.3 GB
EGAF00003477116 fastq.gz 4.4 GB
EGAF00003477117 fastq.gz 4.4 GB
EGAF00003477118 fastq.gz 4.7 GB
EGAF00003477119 fastq.gz 4.9 GB
EGAF00003477120 fastq.gz 5.0 GB
EGAF00003477121 fastq.gz 4.5 GB
EGAF00003477122 fastq.gz 4.7 GB
EGAF00003477123 fastq.gz 4.3 GB
EGAF00003477124 fastq.gz 4.3 GB
EGAF00003477125 fastq.gz 3.4 GB
EGAF00003477126 fastq.gz 3.4 GB
EGAF00003477127 fastq.gz 4.2 GB
EGAF00003477128 fastq.gz 4.2 GB
EGAF00003477129 fastq.gz 3.8 GB
EGAF00003477130 fastq.gz 3.8 GB
EGAF00003477131 fastq.gz 4.3 GB
EGAF00003477132 fastq.gz 4.5 GB
EGAF00003477133 fastq.gz 4.1 GB
EGAF00003477134 fastq.gz 4.2 GB
EGAF00003477135 fastq.gz 4.4 GB
EGAF00003477136 fastq.gz 4.5 GB
EGAF00003477137 fastq.gz 4.1 GB
EGAF00003477138 fastq.gz 4.2 GB
EGAF00003477139 fastq.gz 4.2 GB
EGAF00003477140 fastq.gz 4.3 GB
EGAF00003477141 fastq.gz 4.1 GB
EGAF00003477142 fastq.gz 4.3 GB
EGAF00003477143 fastq.gz 4.3 GB
EGAF00003477144 fastq.gz 4.4 GB
EGAF00003477145 fastq.gz 4.3 GB
EGAF00003477146 fastq.gz 4.4 GB
EGAF00003477147 fastq.gz 4.4 GB
EGAF00003477148 fastq.gz 4.6 GB
EGAF00003477149 fastq.gz 4.7 GB
EGAF00003477150 fastq.gz 4.9 GB
EGAF00003477151 fastq.gz 4.1 GB
EGAF00003477152 fastq.gz 4.2 GB
EGAF00003477153 fastq.gz 4.2 GB
EGAF00003477154 fastq.gz 4.3 GB
EGAF00003477155 fastq.gz 5.1 GB
EGAF00003477156 fastq.gz 5.2 GB
EGAF00003477157 fastq.gz 4.0 GB
EGAF00003477158 fastq.gz 4.0 GB
EGAF00003477159 fastq.gz 5.0 GB
EGAF00003477160 fastq.gz 5.1 GB
EGAF00003477161 fastq.gz 3.6 GB
EGAF00003477162 fastq.gz 3.6 GB
EGAF00003477163 fastq.gz 4.2 GB
EGAF00003477164 fastq.gz 4.2 GB
EGAF00003477165 fastq.gz 5.1 GB
EGAF00003477166 fastq.gz 5.2 GB
EGAF00003477167 fastq.gz 4.8 GB
EGAF00003477168 fastq.gz 4.8 GB
EGAF00003477169 fastq.gz 4.3 GB
EGAF00003477170 fastq.gz 4.4 GB
EGAF00003477171 fastq.gz 4.0 GB
EGAF00003477172 fastq.gz 4.1 GB
EGAF00003477173 fastq.gz 4.2 GB
EGAF00003477174 fastq.gz 4.2 GB
EGAF00003477175 fastq.gz 4.0 GB
EGAF00003477176 fastq.gz 4.2 GB
EGAF00003477177 fastq.gz 4.4 GB
EGAF00003477178 fastq.gz 4.4 GB
EGAF00003477179 fastq.gz 6.1 GB
EGAF00003477180 fastq.gz 6.3 GB
EGAF00003477181 fastq.gz 4.9 GB
EGAF00003477182 fastq.gz 5.0 GB
EGAF00003477183 fastq.gz 4.4 GB
EGAF00003477184 fastq.gz 4.5 GB
EGAF00003477185 fastq.gz 4.3 GB
EGAF00003477186 fastq.gz 4.5 GB
EGAF00003477187 fastq.gz 4.1 GB
EGAF00003477188 fastq.gz 4.0 GB
EGAF00003477189 fastq.gz 3.6 GB
EGAF00003477190 fastq.gz 3.8 GB
EGAF00003477191 fastq.gz 5.0 GB
EGAF00003477192 fastq.gz 5.3 GB
EGAF00003477193 fastq.gz 2.5 GB
EGAF00003477194 fastq.gz 2.5 GB
EGAF00003477195 fastq.gz 2.1 GB
EGAF00003477196 fastq.gz 2.1 GB
EGAF00003477197 fastq.gz 1.7 GB
EGAF00003477198 fastq.gz 1.8 GB
EGAF00003477199 fastq.gz 2.4 GB
EGAF00003477200 fastq.gz 2.5 GB
EGAF00003477201 fastq.gz 1.7 GB
EGAF00003477202 fastq.gz 1.8 GB
EGAF00003477203 fastq.gz 2.3 GB
EGAF00003477204 fastq.gz 2.4 GB
EGAF00003477205 fastq.gz 2.1 GB
EGAF00003477206 fastq.gz 2.2 GB
EGAF00003477207 fastq.gz 2.5 GB
EGAF00003477208 fastq.gz 2.6 GB
EGAF00003477209 fastq.gz 2.5 GB
EGAF00003477210 fastq.gz 2.6 GB
EGAF00003477211 fastq.gz 2.2 GB
EGAF00003477212 fastq.gz 2.3 GB
EGAF00003477213 fastq.gz 1.5 GB
EGAF00003477214 fastq.gz 1.6 GB
EGAF00003477215 fastq.gz 1.9 GB
EGAF00003477216 fastq.gz 2.0 GB
EGAF00003477217 fastq.gz 2.5 GB
EGAF00003477218 fastq.gz 2.5 GB
EGAF00003477219 fastq.gz 2.2 GB
EGAF00003477220 fastq.gz 2.3 GB
EGAF00003477221 fastq.gz 2.1 GB
EGAF00003477222 fastq.gz 2.2 GB
EGAF00003477223 fastq.gz 1.9 GB
EGAF00003477224 fastq.gz 2.0 GB
EGAF00003477225 fastq.gz 2.5 GB
EGAF00003477226 fastq.gz 2.5 GB
EGAF00003477227 fastq.gz 1.7 GB
EGAF00003477228 fastq.gz 1.8 GB
EGAF00003477229 fastq.gz 1.6 GB
EGAF00003477230 fastq.gz 1.7 GB
EGAF00003477231 fastq.gz 1.9 GB
EGAF00003477232 fastq.gz 2.0 GB
EGAF00003477233 fastq.gz 6.7 GB
EGAF00003477234 fastq.gz 6.9 GB
EGAF00003477235 fastq.gz 1.9 GB
EGAF00003477236 fastq.gz 1.9 GB
EGAF00003477237 fastq.gz 1.7 GB
EGAF00003477238 fastq.gz 1.8 GB
EGAF00003477239 fastq.gz 2.0 GB
EGAF00003477240 fastq.gz 2.2 GB
EGAF00003477241 fastq.gz 1.6 GB
EGAF00003477242 fastq.gz 1.7 GB
EGAF00003477243 fastq.gz 2.5 GB
EGAF00003477244 fastq.gz 2.6 GB
EGAF00003477245 fastq.gz 3.9 GB
EGAF00003477246 fastq.gz 4.1 GB
EGAF00003477247 fastq.gz 2.4 GB
EGAF00003477248 fastq.gz 2.5 GB
EGAF00003477249 fastq.gz 2.0 GB
EGAF00003477250 fastq.gz 2.1 GB
EGAF00003477251 fastq.gz 2.4 GB
EGAF00003477252 fastq.gz 2.4 GB
EGAF00003477253 fastq.gz 2.0 GB
EGAF00003477254 fastq.gz 2.1 GB
EGAF00003477255 fastq.gz 2.6 GB
EGAF00003477256 fastq.gz 2.7 GB
EGAF00003477257 fastq.gz 1.8 GB
EGAF00003477258 fastq.gz 1.8 GB
EGAF00003477259 fastq.gz 1.5 GB
EGAF00003477260 fastq.gz 1.6 GB
EGAF00003477261 fastq.gz 2.3 GB
EGAF00003477262 fastq.gz 2.3 GB
EGAF00003477263 fastq.gz 2.1 GB
EGAF00003477264 fastq.gz 2.1 GB
EGAF00003477265 fastq.gz 1.8 GB
EGAF00003477266 fastq.gz 1.8 GB
EGAF00003477267 fastq.gz 2.4 GB
EGAF00003477268 fastq.gz 2.7 GB
EGAF00003477269 fastq.gz 1.1 GB
EGAF00003477270 fastq.gz 1.1 GB
EGAF00003477271 fastq.gz 2.2 GB
EGAF00003477272 fastq.gz 2.3 GB
EGAF00003477273 fastq.gz 1.7 GB
EGAF00003477274 fastq.gz 1.8 GB
EGAF00003477275 fastq.gz 2.6 GB
EGAF00003477276 fastq.gz 2.7 GB
EGAF00003477277 fastq.gz 1.9 GB
EGAF00003477278 fastq.gz 2.1 GB
EGAF00003477279 fastq.gz 2.2 GB
EGAF00003477280 fastq.gz 2.3 GB
EGAF00003477281 fastq.gz 2.6 GB
EGAF00003477282 fastq.gz 2.7 GB
EGAF00003477283 fastq.gz 2.0 GB
EGAF00003477284 fastq.gz 2.1 GB
EGAF00003477285 fastq.gz 1.9 GB
EGAF00003477286 fastq.gz 2.0 GB
EGAF00003477287 fastq.gz 2.7 GB
EGAF00003477288 fastq.gz 2.8 GB
EGAF00003477289 fastq.gz 2.4 GB
EGAF00003477290 fastq.gz 2.6 GB
EGAF00003477291 fastq.gz 2.6 GB
EGAF00003477292 fastq.gz 2.8 GB
EGAF00003477293 fastq.gz 2.4 GB
EGAF00003477294 fastq.gz 2.5 GB
EGAF00003477295 fastq.gz 2.9 GB
EGAF00003477296 fastq.gz 3.0 GB
EGAF00003477297 fastq.gz 2.1 GB
EGAF00003477298 fastq.gz 2.3 GB
EGAF00003477299 fastq.gz 1.9 GB
EGAF00003477300 fastq.gz 2.0 GB
EGAF00003477301 fastq.gz 2.4 GB
EGAF00003477302 fastq.gz 2.4 GB
EGAF00003477303 fastq.gz 1.8 GB
EGAF00003477304 fastq.gz 1.9 GB
EGAF00003477305 fastq.gz 1.9 GB
EGAF00003477306 fastq.gz 2.0 GB
EGAF00003477307 fastq.gz 1.8 GB
EGAF00003477308 fastq.gz 1.9 GB
EGAF00003477309 fastq.gz 1.2 GB
EGAF00003477310 fastq.gz 1.2 GB
EGAF00003477311 fastq.gz 3.0 GB
EGAF00003477312 fastq.gz 3.0 GB
EGAF00003477313 fastq.gz 1.8 GB
EGAF00003477314 fastq.gz 1.9 GB
EGAF00003477315 fastq.gz 2.4 GB
EGAF00003477316 fastq.gz 2.6 GB
EGAF00003477317 fastq.gz 2.0 GB
EGAF00003477318 fastq.gz 2.0 GB
EGAF00003477319 fastq.gz 1.8 GB
EGAF00003477320 fastq.gz 2.0 GB
EGAF00003477321 fastq.gz 1.3 GB
EGAF00003477322 fastq.gz 1.3 GB
EGAF00003477323 fastq.gz 1.8 GB
EGAF00003477324 fastq.gz 1.9 GB
EGAF00003477325 fastq.gz 2.7 GB
EGAF00003477326 fastq.gz 2.8 GB
EGAF00003477327 fastq.gz 1.2 GB
EGAF00003477328 fastq.gz 1.3 GB
EGAF00003477329 fastq.gz 2.6 GB
EGAF00003477330 fastq.gz 2.6 GB
EGAF00003477331 fastq.gz 2.6 GB
EGAF00003477332 fastq.gz 2.5 GB
EGAF00003477333 fastq.gz 2.3 GB
EGAF00003477334 fastq.gz 2.2 GB
EGAF00003477335 fastq.gz 2.4 GB
EGAF00003477336 fastq.gz 2.4 GB
EGAF00003477337 fastq.gz 2.0 GB
EGAF00003477338 fastq.gz 2.3 GB
EGAF00003477339 fastq.gz 2.1 GB
EGAF00003477340 fastq.gz 2.2 GB
EGAF00003477341 fastq.gz 1.7 GB
EGAF00003477342 fastq.gz 1.7 GB
EGAF00003477343 fastq.gz 1.6 GB
EGAF00003477344 fastq.gz 1.7 GB
EGAF00003477345 fastq.gz 1.6 GB
EGAF00003477346 fastq.gz 1.6 GB
EGAF00003477347 fastq.gz 2.1 GB
EGAF00003477348 fastq.gz 2.2 GB
EGAF00003477349 fastq.gz 2.0 GB
EGAF00003477350 fastq.gz 2.1 GB
EGAF00003477351 fastq.gz 2.5 GB
EGAF00003477352 fastq.gz 2.5 GB
556 Files (2.5 TB)