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Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform

We used 200 ccRCC samples from 51 tumors to simultaneously isolate DNA, RNA, and protein according to established protocol. RNA quality was assessed using an Agilent Bioanalyzer, and total RNA with RIN>7 was used for further RNA sequencing. 184 ccRCC samples from 49 tumors passing initial quality control underwent RNA sequencing at Admera Health Inc. (Genohub Inc., Austin, TX). RNA sequencing libraries were prepared using the Illumina TruSeq Stranded mRNA high throughput (HT) sample preparation kit following the manufacturers’ protocol. Pair-end RNA Seq data was deposited in this cohort.

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Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal cell Carcinoma (ccRCC) with percutaneous biopsies and is a confounding factor in selection of molecular-targeted versus immune-based therapy. Magnetic Resonance (MR) Imaging can noninvasively assess the spatial landscape of the entire tumor. To validate MRI for ITH assessment, we implemented a radiogenomic platform through a systematic imaging based co-localization approach for multi region tissue acquisition from single tumors. We investigated if the spatial changes in imaging can predict the molecular changes using transcriptome and histopathological correlatives. Our study confirmed imaging heterogeneity as a predictor of molecular heterogeneity in ccRCC.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom Ivan Pedrosa grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Ivan Pedrosa and the collaborators listed in Appendix I responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. XXXXX: Your Institution details here 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organization for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify DAC within 30 days of any changes or departures of Authorized Personnel. 13. The User Institution will notify DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for Ivan Pedrosa Signature: Name: Ivan Pedrosa Title: Professor Date: Agreed for UTSW authorized official Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) EGAS00001003846 Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal cell Carcinoma (ccRCC) with percutaneous biopsies and is a confounding factor in selection of molecular-targeted versus immune-based therapy. Magnetic Resonance (MR) Imaging can noninvasively assess the spatial landscape of the entire tumor. To validate MRI for ITH assessment, we implemented a radiogenomic platform through a systematic imaging based co-localization approach for multi region tissue acquisition from single tumors. We investigated if the spatial changes in imaging can predict the molecular changes using transcriptome and histopathological correlatives. Our study confirmed imaging heterogeneity as a predictor of molecular heterogeneity in ccRCC. Name of project that created the dataset Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform Names of other data producers/collaborators Ivan Pedrosa, Durga Udayakumar Specific limitations on areas of research Academic research Minimum protection measures required The data should be accessed by only the persons listed in the agreement between User and DAC. The data should be stored on a computer system behind the network firewall and the network to which the computer system storing data is connected should not be exposed the public internet. File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY Ivan Pedrosa and the collaborators listed in Appendix I intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. Ivan Pedrosa and the collaborators listed in Appendix I anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 12 months after these data were first made available on the relevant hosting database, unless DAC has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with DAC.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002637581 fastq.gz 8.6 GB
EGAF00002637591 fastq.gz 5.4 GB
EGAF00002637596 fastq.gz 12.3 GB
EGAF00002637599 fastq.gz 7.1 GB
EGAF00002637602 fastq.gz 7.6 GB
EGAF00002637625 fastq.gz 6.8 GB
EGAF00002637634 fastq.gz 5.6 GB
EGAF00002637636 fastq.gz 5.2 GB
EGAF00002637640 fastq.gz 4.4 GB
EGAF00002637642 fastq.gz 9.1 GB
EGAF00002637645 fastq.gz 4.6 GB
EGAF00002637646 fastq.gz 5.3 GB
EGAF00002637649 fastq.gz 7.6 GB
EGAF00002637655 fastq.gz 5.3 GB
EGAF00002637678 fastq.gz 8.5 GB
EGAF00002637681 fastq.gz 6.6 GB
EGAF00002637683 fastq.gz 7.2 GB
EGAF00002637712 fastq.gz 5.9 GB
EGAF00002637717 fastq.gz 17.1 GB
EGAF00002637718 fastq.gz 19.6 GB
EGAF00002637719 fastq.gz 6.5 GB
EGAF00002637720 fastq.gz 7.5 GB
EGAF00002637721 fastq.gz 5.1 GB
EGAF00002637723 fastq.gz 4.8 GB
EGAF00002637725 fastq.gz 8.0 GB
EGAF00002637726 fastq.gz 8.4 GB
EGAF00002637729 fastq.gz 9.0 GB
EGAF00002637731 fastq.gz 6.8 GB
EGAF00002637732 fastq.gz 7.9 GB
EGAF00002637733 fastq.gz 6.8 GB
EGAF00002637734 fastq.gz 7.9 GB
EGAF00002637735 fastq.gz 6.8 GB
EGAF00002637741 fastq.gz 6.5 GB
EGAF00002637744 fastq.gz 4.1 GB
EGAF00002637747 fastq.gz 5.0 GB
EGAF00002637748 fastq.gz 5.4 GB
EGAF00002637774 fastq.gz 8.7 GB
EGAF00002637781 fastq.gz 7.3 GB
EGAF00002637782 fastq.gz 4.5 GB
EGAF00002637783 fastq.gz 11.3 GB
EGAF00002637784 fastq.gz 12.9 GB
EGAF00002637785 fastq.gz 5.2 GB
EGAF00002637786 fastq.gz 5.5 GB
EGAF00002637789 fastq.gz 10.0 GB
EGAF00002637790 fastq.gz 10.2 GB
EGAF00002637792 fastq.gz 8.1 GB
EGAF00002637793 fastq.gz 6.2 GB
EGAF00002637794 fastq.gz 3.7 GB
EGAF00002637795 fastq.gz 7.6 GB
EGAF00002637796 fastq.gz 8.5 GB
EGAF00002637797 fastq.gz 6.4 GB
EGAF00002637798 fastq.gz 3.8 GB
EGAF00002637799 fastq.gz 6.7 GB
EGAF00002637801 fastq.gz 5.9 GB
EGAF00002637802 fastq.gz 6.4 GB
EGAF00002637804 fastq.gz 6.1 GB
EGAF00002637805 fastq.gz 4.8 GB
EGAF00002637806 fastq.gz 5.5 GB
EGAF00002637809 fastq.gz 11.1 GB
EGAF00002637811 fastq.gz 4.7 GB
EGAF00002637812 fastq.gz 5.1 GB
EGAF00002637813 fastq.gz 8.8 GB
EGAF00002637815 fastq.gz 6.8 GB
EGAF00002637816 fastq.gz 7.8 GB
EGAF00002637817 fastq.gz 6.6 GB
EGAF00002637818 fastq.gz 7.4 GB
EGAF00002637819 fastq.gz 8.7 GB
EGAF00002637835 fastq.gz 6.7 GB
EGAF00002637841 fastq.gz 7.1 GB
EGAF00002637842 fastq.gz 8.0 GB
EGAF00002637847 fastq.gz 7.1 GB
EGAF00002637849 fastq.gz 6.2 GB
EGAF00002637850 fastq.gz 6.6 GB
EGAF00002637851 fastq.gz 5.1 GB
EGAF00002637853 fastq.gz 8.4 GB
EGAF00002637854 fastq.gz 9.6 GB
EGAF00002637856 fastq.gz 7.0 GB
EGAF00002637857 fastq.gz 7.8 GB
EGAF00002637858 fastq.gz 8.7 GB
EGAF00002637861 fastq.gz 6.8 GB
EGAF00002637862 fastq.gz 4.1 GB
EGAF00002637865 fastq.gz 7.3 GB
EGAF00002637866 fastq.gz 7.9 GB
EGAF00002637870 fastq.gz 7.6 GB
EGAF00002637871 fastq.gz 9.4 GB
EGAF00002637872 fastq.gz 10.6 GB
EGAF00002637875 fastq.gz 5.3 GB
EGAF00002637884 fastq.gz 4.1 GB
EGAF00002637885 fastq.gz 7.7 GB
EGAF00002637886 fastq.gz 8.5 GB
EGAF00002637887 fastq.gz 7.4 GB
EGAF00002637889 fastq.gz 10.5 GB
EGAF00002637890 fastq.gz 6.3 GB
EGAF00002637892 fastq.gz 6.9 GB
EGAF00002637894 fastq.gz 8.9 GB
EGAF00002637898 fastq.gz 7.8 GB
EGAF00002637899 fastq.gz 6.4 GB
EGAF00002637900 fastq.gz 7.1 GB
EGAF00002637901 fastq.gz 8.9 GB
EGAF00002637902 fastq.gz 9.9 GB
EGAF00002637903 fastq.gz 4.9 GB
EGAF00002637904 fastq.gz 5.4 GB
EGAF00002637905 fastq.gz 7.0 GB
EGAF00002637906 fastq.gz 7.7 GB
EGAF00002637907 fastq.gz 5.5 GB
EGAF00002637908 fastq.gz 6.2 GB
EGAF00002637909 fastq.gz 8.4 GB
EGAF00002637910 fastq.gz 9.5 GB
EGAF00002637913 fastq.gz 5.3 GB
EGAF00002637917 fastq.gz 6.0 GB
EGAF00002637918 fastq.gz 6.7 GB
EGAF00002637919 fastq.gz 7.4 GB
EGAF00002637920 fastq.gz 8.4 GB
EGAF00002637925 fastq.gz 7.7 GB
EGAF00002637927 fastq.gz 7.7 GB
EGAF00002637930 fastq.gz 9.9 GB
EGAF00002637943 fastq.gz 5.7 GB
EGAF00002637944 fastq.gz 6.4 GB
EGAF00002637948 fastq.gz 4.1 GB
EGAF00002637952 fastq.gz 5.5 GB
EGAF00002637961 fastq.gz 9.7 GB
EGAF00002637962 fastq.gz 9.8 GB
EGAF00002637963 fastq.gz 4.7 GB
EGAF00002637964 fastq.gz 5.2 GB
EGAF00002637965 fastq.gz 6.0 GB
EGAF00002637966 fastq.gz 3.7 GB
EGAF00002637967 fastq.gz 5.2 GB
EGAF00002637968 fastq.gz 5.6 GB
EGAF00002637969 fastq.gz 6.0 GB
EGAF00002637970 fastq.gz 6.8 GB
EGAF00002637971 fastq.gz 9.7 GB
EGAF00002637972 fastq.gz 11.1 GB
EGAF00002637976 fastq.gz 15.2 GB
EGAF00002637985 fastq.gz 9.7 GB
EGAF00002637991 fastq.gz 5.3 GB
EGAF00002637992 fastq.gz 6.1 GB
EGAF00002638007 fastq.gz 6.4 GB
EGAF00002638008 fastq.gz 3.8 GB
EGAF00002638009 fastq.gz 7.6 GB
EGAF00002638011 fastq.gz 6.8 GB
EGAF00002638014 fastq.gz 5.9 GB
EGAF00002638016 fastq.gz 8.0 GB
EGAF00002638020 fastq.gz 7.1 GB
EGAF00002638027 fastq.gz 9.7 GB
EGAF00002638029 fastq.gz 4.7 GB
EGAF00002638030 fastq.gz 5.2 GB
EGAF00002638031 fastq.gz 7.5 GB
EGAF00002638032 fastq.gz 4.6 GB
EGAF00002638038 fastq.gz 8.4 GB
EGAF00002638039 fastq.gz 6.4 GB
EGAF00002638041 fastq.gz 8.4 GB
EGAF00002638042 fastq.gz 9.4 GB
EGAF00002638047 fastq.gz 5.2 GB
EGAF00002638048 fastq.gz 5.9 GB
EGAF00002638051 fastq.gz 6.9 GB
EGAF00002638052 fastq.gz 7.6 GB
EGAF00002638061 fastq.gz 5.5 GB
EGAF00002638062 fastq.gz 6.3 GB
EGAF00002638063 fastq.gz 7.0 GB
EGAF00002638064 fastq.gz 7.9 GB
EGAF00002638071 fastq.gz 7.2 GB
EGAF00002638073 fastq.gz 6.4 GB
EGAF00002638074 fastq.gz 3.8 GB
EGAF00002638075 fastq.gz 6.9 GB
EGAF00002638078 fastq.gz 7.6 GB
EGAF00002638079 fastq.gz 5.4 GB
EGAF00002638080 fastq.gz 6.0 GB
EGAF00002638082 fastq.gz 3.8 GB
EGAF00002638083 fastq.gz 8.4 GB
EGAF00002638084 fastq.gz 5.0 GB
EGAF00002638086 fastq.gz 4.5 GB
EGAF00002638092 fastq.gz 5.9 GB
EGAF00002638093 fastq.gz 7.2 GB
EGAF00002638096 fastq.gz 7.5 GB
EGAF00002638098 fastq.gz 6.0 GB
EGAF00002638099 fastq.gz 5.8 GB
EGAF00002638100 fastq.gz 6.5 GB
EGAF00002638101 fastq.gz 8.2 GB
EGAF00002638102 fastq.gz 4.9 GB
EGAF00002638103 fastq.gz 4.7 GB
EGAF00002638105 fastq.gz 7.0 GB
EGAF00002638106 fastq.gz 8.0 GB
EGAF00002638108 fastq.gz 9.5 GB
EGAF00002638109 fastq.gz 5.3 GB
EGAF00002638110 fastq.gz 6.0 GB
EGAF00002638111 fastq.gz 5.8 GB
EGAF00002638112 fastq.gz 6.5 GB
EGAF00002638113 fastq.gz 6.0 GB
EGAF00002638114 fastq.gz 6.7 GB
EGAF00002638115 fastq.gz 7.6 GB
EGAF00002638116 fastq.gz 8.3 GB
EGAF00002638117 fastq.gz 5.4 GB
EGAF00002638118 fastq.gz 6.2 GB
EGAF00002638119 fastq.gz 7.7 GB
EGAF00002638120 fastq.gz 4.6 GB
EGAF00002638122 fastq.gz 4.2 GB
EGAF00002638123 fastq.gz 6.9 GB
EGAF00002638124 fastq.gz 7.9 GB
EGAF00002638127 fastq.gz 5.8 GB
EGAF00002638128 fastq.gz 6.5 GB
EGAF00002638130 fastq.gz 14.5 GB
EGAF00002638131 fastq.gz 6.3 GB
EGAF00002638133 fastq.gz 10.4 GB
EGAF00002638134 fastq.gz 12.0 GB
EGAF00002638135 fastq.gz 6.7 GB
EGAF00002638136 fastq.gz 4.1 GB
EGAF00002638137 fastq.gz 13.6 GB
EGAF00002638138 fastq.gz 15.2 GB
EGAF00002638139 fastq.gz 12.2 GB
EGAF00002638140 fastq.gz 13.6 GB
EGAF00002638141 fastq.gz 6.7 GB
EGAF00002638142 fastq.gz 7.6 GB
EGAF00002638143 fastq.gz 6.7 GB
EGAF00002638145 fastq.gz 6.7 GB
EGAF00002638146 fastq.gz 7.5 GB
EGAF00002638147 fastq.gz 8.6 GB
EGAF00002638148 fastq.gz 9.5 GB
EGAF00002638149 fastq.gz 5.0 GB
EGAF00002638150 fastq.gz 5.7 GB
EGAF00002638151 fastq.gz 9.2 GB
EGAF00002638152 fastq.gz 5.5 GB
EGAF00002638153 fastq.gz 5.0 GB
EGAF00002638154 fastq.gz 5.7 GB
EGAF00002638155 fastq.gz 7.7 GB
EGAF00002638156 fastq.gz 8.6 GB
EGAF00002638157 fastq.gz 9.0 GB
EGAF00002638158 fastq.gz 10.3 GB
EGAF00002638159 fastq.gz 8.5 GB
EGAF00002638160 fastq.gz 5.0 GB
EGAF00002638161 fastq.gz 5.8 GB
EGAF00002638162 fastq.gz 6.6 GB
EGAF00002638163 fastq.gz 6.3 GB
EGAF00002638164 fastq.gz 3.6 GB
EGAF00002638165 fastq.gz 5.7 GB
EGAF00002638166 fastq.gz 6.5 GB
EGAF00002638169 fastq.gz 9.3 GB
EGAF00002638170 fastq.gz 10.0 GB
EGAF00002638171 fastq.gz 6.9 GB
EGAF00002638172 fastq.gz 4.2 GB
EGAF00002638173 fastq.gz 7.7 GB
EGAF00002638175 fastq.gz 6.8 GB
EGAF00002638176 fastq.gz 4.1 GB
EGAF00002638177 fastq.gz 7.2 GB
EGAF00002638178 fastq.gz 8.1 GB
EGAF00002638179 fastq.gz 5.2 GB
EGAF00002638180 fastq.gz 6.0 GB
EGAF00002638181 fastq.gz 6.8 GB
EGAF00002638183 fastq.gz 6.9 GB
EGAF00002638184 fastq.gz 7.7 GB
EGAF00002638185 fastq.gz 5.5 GB
EGAF00002638186 fastq.gz 6.0 GB
EGAF00002638187 fastq.gz 5.8 GB
EGAF00002638188 fastq.gz 6.4 GB
EGAF00002638190 fastq.gz 6.0 GB
EGAF00002638193 fastq.gz 5.4 GB
EGAF00002638194 fastq.gz 6.1 GB
EGAF00002638195 fastq.gz 9.1 GB
EGAF00002638196 fastq.gz 10.0 GB
EGAF00002638197 fastq.gz 6.8 GB
EGAF00002638198 fastq.gz 4.1 GB
EGAF00002638199 fastq.gz 7.8 GB
EGAF00002638200 fastq.gz 4.7 GB
EGAF00002638201 fastq.gz 7.2 GB
EGAF00002638202 fastq.gz 7.9 GB
EGAF00002638203 fastq.gz 8.9 GB
EGAF00002638204 fastq.gz 9.8 GB
EGAF00002638205 fastq.gz 6.8 GB
EGAF00002638206 fastq.gz 7.5 GB
EGAF00002638207 fastq.gz 5.2 GB
EGAF00002638208 fastq.gz 5.9 GB
EGAF00002638209 fastq.gz 5.5 GB
EGAF00002638210 fastq.gz 5.8 GB
EGAF00002638211 fastq.gz 7.6 GB
EGAF00002638212 fastq.gz 4.5 GB
EGAF00002638213 fastq.gz 8.3 GB
EGAF00002638214 fastq.gz 8.7 GB
EGAF00002638215 fastq.gz 4.7 GB
EGAF00002638216 fastq.gz 5.3 GB
EGAF00002638217 fastq.gz 5.4 GB
EGAF00002638218 fastq.gz 6.0 GB
EGAF00002638221 fastq.gz 4.7 GB
EGAF00002638222 fastq.gz 5.0 GB
EGAF00002638223 fastq.gz 7.2 GB
EGAF00002638224 fastq.gz 4.3 GB
EGAF00002638225 fastq.gz 7.7 GB
EGAF00002638226 fastq.gz 4.6 GB
EGAF00002638227 fastq.gz 6.7 GB
EGAF00002638228 fastq.gz 7.3 GB
EGAF00002638229 fastq.gz 7.6 GB
EGAF00002638230 fastq.gz 4.6 GB
EGAF00002638231 fastq.gz 6.4 GB
EGAF00002638232 fastq.gz 3.8 GB
EGAF00002638233 fastq.gz 7.3 GB
EGAF00002638234 fastq.gz 4.4 GB
EGAF00002638235 fastq.gz 5.6 GB
EGAF00002638236 fastq.gz 6.3 GB
EGAF00002638237 fastq.gz 5.2 GB
EGAF00002638238 fastq.gz 5.8 GB
EGAF00002638241 fastq.gz 5.3 GB
EGAF00002638242 fastq.gz 5.9 GB
EGAF00002638243 fastq.gz 6.1 GB
EGAF00002638244 fastq.gz 6.6 GB
EGAF00002638245 fastq.gz 4.6 GB
EGAF00002638246 fastq.gz 5.0 GB
EGAF00002638247 fastq.gz 12.7 GB
EGAF00002638248 fastq.gz 14.5 GB
EGAF00002638249 fastq.gz 6.3 GB
EGAF00002638250 fastq.gz 7.0 GB
EGAF00002638251 fastq.gz 6.8 GB
EGAF00002638252 fastq.gz 7.7 GB
EGAF00002638253 fastq.gz 6.1 GB
EGAF00002638254 fastq.gz 6.7 GB
EGAF00002638255 fastq.gz 5.3 GB
EGAF00002638256 fastq.gz 3.7 GB
EGAF00002638257 fastq.gz 4.7 GB
EGAF00002638258 fastq.gz 5.2 GB
EGAF00002638259 fastq.gz 7.3 GB
EGAF00002638260 fastq.gz 4.4 GB
EGAF00002638261 fastq.gz 7.2 GB
EGAF00002638262 fastq.gz 4.3 GB
EGAF00002638263 fastq.gz 9.6 GB
EGAF00002638264 fastq.gz 10.7 GB
EGAF00002638265 fastq.gz 5.9 GB
EGAF00002638266 fastq.gz 3.5 GB
EGAF00002638267 fastq.gz 8.1 GB
EGAF00002638268 fastq.gz 4.8 GB
EGAF00002638270 fastq.gz 7.5 GB
EGAF00002638271 fastq.gz 11.2 GB
EGAF00002638272 fastq.gz 12.5 GB
EGAF00002638273 fastq.gz 5.3 GB
EGAF00002638274 fastq.gz 5.6 GB
EGAF00002638275 fastq.gz 10.6 GB
EGAF00002638276 fastq.gz 11.4 GB
EGAF00002638277 fastq.gz 7.8 GB
EGAF00002638278 fastq.gz 8.5 GB
EGAF00002638279 fastq.gz 6.5 GB
EGAF00002638280 fastq.gz 7.1 GB
EGAF00002638281 fastq.gz 5.9 GB
EGAF00002638282 fastq.gz 6.0 GB
EGAF00002638283 fastq.gz 6.7 GB
EGAF00002638284 fastq.gz 4.0 GB
EGAF00002638285 fastq.gz 9.8 GB
EGAF00002638286 fastq.gz 5.9 GB
EGAF00002638289 fastq.gz 6.7 GB
EGAF00002638290 fastq.gz 7.3 GB
EGAF00002638291 fastq.gz 5.4 GB
EGAF00002638292 fastq.gz 6.1 GB
EGAF00002638293 fastq.gz 16.7 GB
EGAF00002638294 fastq.gz 19.0 GB
EGAF00002638296 fastq.gz 5.2 GB
EGAF00002638297 fastq.gz 8.6 GB
EGAF00002638298 fastq.gz 9.9 GB
EGAF00002638299 fastq.gz 6.9 GB
EGAF00002638300 fastq.gz 7.8 GB
EGAF00002638301 fastq.gz 6.0 GB
EGAF00002638302 fastq.gz 6.6 GB
EGAF00002638303 fastq.gz 4.9 GB
EGAF00002638304 fastq.gz 2.8 GB
EGAF00002638305 fastq.gz 5.2 GB
EGAF00002638306 fastq.gz 3.0 GB
EGAF00002640861 fastq.gz 13.7 GB
EGAF00002640862 fastq.gz 15.5 GB
362 Files (2.6 TB)