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Single cell RNA sequencing of colorectal cancer

To understand intrinsic cancer cell signatures and the surrounding microenvironemt and their interactions, we performed single-cell RNA sequencing on 63,689 cells from 23 patients with 23 primary colorectal cancer and 10 matched normal mucosa samples. Analyzing of primary colorectal cancer and normal mucosa samples show a comprehensive cellular landscape of colon cancer, which is a valuable resource for the development of therapeutic strategies.

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DATA TRANSFER AGREEMENT For Non-Profit Research Purposes (DTA)

DATA TRANSFER AGREEMENT For Non-Profit Research Purposes (DTA) Whereas, [Samsung Medical Center], [81, Irwon-ro, Gangnam-gu, Seoul, Korea, 06351] (hereinafter "SMC") possesses certain data consisting of ------------------- (hereinafter "Data") and; Whereas, [Insert Institution Details], [Institution’s address] (hereinafter “000”) is to obtain from SMC such Data for the purpose to ---------------------------- (hereinafter "Research"). In response to the 000’s request for access to the Data (as defined below), SMC and the 000 agree as follows: 1. Ownership SMC retains title and all rights to the Data, subject to the rights granted herein. Nothing contained within this Agreement shall restrict SMC's right to distribute the Data to other commercial or noncommercial entities. 2. Use “000” agrees that the Data : a) shall be used for scientific research purposes only; and b) shall not be used, directly or indirectly, for commercial purposes, including filing patent applications thereon, except for the purpose described above. 3. Distribution and Control “000” agrees not to transfer the Data to any third party without the prior written permission of SMC. In addition, “000” shall obtain acceptance of the terms of this Agreement of all persons under its direct control and supervision who have access to the Data. 4. Confidentiality “000” agrees to use reasonable efforts to hold in confidence, after receipt, all Information received from SMC under this Agreement, except for Information which: a) was lawfully in 000's possession or control prior to the date of disclosure; or b) was in the public domain or enters into the public domain through no improper act on 000's part or on the part of any of 000's employees; c) is rightfully given to “000” from sources independent of SMC; or d) must be disclosed for minimum lawful compliance with court orders, regulations and statutes; or e) is part of a publication that is subject to Clause 7 and receives approval for publication by SMC. 5. Data Protection The “000” agrees that it, and its Registered Users, shall not analyse or make any use of the Data in such a way that has the potential to: a) Lead to the identification of any Data Subject; or b) Compromise the anonymity of any Data Subject in any way. 6. Transfer of Rights NO right or license is granted under this Agreement by either party to the other either expressly or by implication, except those specifically set forth herein. It is understood that any and all proprietary rights, including but not limited to patent rights, trademarks and proprietary rights, in and to the Data shall be and remain in SMC, subject to the rights granted herein. 7. Inventions If the Research which involves the Data results in an invention, improvement or substance, whether or not patentable, “000” agrees to disclose promptly to SMC all such inventions, improvements or substances, and SMC will file or will arrange to have filed a application for said Invention. “000” shall cooperate with SMC, in seeking patent coverage for such Invention and expenses for seeking patent coverage for such invention will be paid by SMC. SMC shall have control of strategy and expenses with respect to patent application filing and prosecution and will give consideration to “000”’s input thereto upon request. As consideration for the receipt of the Data from SMC, the “000” shall grant to SMC 1) a perpetual, royalty-free, non-exclusive worldwide license to all of the 000’s right in Inventions. or 2) an exclusive option, to negotiate a royalty-bearing, sublicenseable, worldwide co-exclusive license to all of the “000”’s right in Inventions. Such agreements may include arrangements to determine potential commercial utility. Inventorship of Invention made in the performance of the Studies shall be determined according to the Republic of Korea patent law. 8. Publication In order to protect SMC's proprietary and/or patent rights to the Data, “000” agrees to provide SMC with a copy of any manuscript or any proposed publication that makes reference to the confidential Data at least thirty (30) days before it is submitted for publication and shall inform SMC of the content of any proposed oral disclosure or submission. If in the opinion of SMC any such publication describes a patentable invention, SMC shall have an opportunity to request that “000” delay publication until after a patent application has been filed. “000” shall delay submission of any publication or disclosure of any result, at the request of SMC, for up to an additional sixty (60) days after receipt by SMC of the proposed publication, in order to permit filing of a patent application. During the thirty (30) days or if request, sixty (60) days period following the submission of a proposed publication or other disclosure to SMC, “000” agree to hold all information contained therein in confidence pending SMC’s review and comment. If a publication does result from work using the Data, “000” agrees to acknowledge SMC and/or give credit to SMC scientists, as scientifically appropriate, based on any direct contribution they may have made to the work. “000” agree that any data in the Studies may be used by SMC for the research purposes, to support SMC patent applications, and in preparing regulatory filings, without any compensation to the “000”. 9. Use of SMC's Name Except as set forth in Article 7, “000” shall not use the name of Samsung Medical Center, or a variant of any of the foregoing in any advertising or publicity matter without the prior written approval of SMC. 10. Reports “000” shall report to SMC at least once every twelve (12) months on 000's work utilizing the Data. 11. Return of Data If this Agreement is terminated, or if “000” does not intend to use the Data, or upon the earlier request of SMC, “000” shall promptly return the Data to SMC or dispose of it in an approved manner, at SMC's discretion. 12. Governmental Regulations “000” agrees to comply with all governmental regulations and guidelines which are applicable to the 000's use of the Data. Since all of the Data's characteristics are not known, it should be used with caution and prudence. 13. Warranty “000” acknowledges that the Data is experimental in nature and that it is provided without warranty of merchantability or fitness for a particular purpose or any other warranty, express or implied. SMC makes no representation that the use of the Data will not infringe any patent, copyright, trademark or other proprietary right. 14. Liability In no event shall SMC be liable for any use of the Data by “000”. To the extent permitted by all governmental laws, “000” hereby agrees to defend, indemnify and hold SMC harmless from any loss, claim, damage or liability, of whatsoever kind or nature, which may arise from 000's acts in connection with this Agreement or the 000's use, handling or storage of the Data. 15. Governing Law The validity and interpretation of this Agreement and the legal relations of the parties to it shall be governed by the laws of the Republic of Korea. 16. Termination This Agreement shall be terminable by either party hereto on thirty (30) days prior written notice to the other but termination shall not relieve “000” of its obligations under this Agreement. 17. Assignment This Agreement may not be assigned by “000” without the prior written consent of SMC. 18. Entire Agreement This Agreement sets forth the entire understanding between the parties and cannot be changed or amended except by written agreement executed by the parties. In witness thereof SMC and “000” have caused this Agreement to be executed in duplicate by their respective duly authorized officers. SIGNATURES FOLLOW ON NEXT PAGE Samsung Medical Center By: _________________________ Name: O Jung Kwon Title: President Date: Scientist Providing Data By: __________________________ Name: Title: Date: [Name of Institution] By: _________________________ Name: Title: Date: Scientist Requesting Data By: __________________________ Name: Title: Date:

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002542464 fastq.gz 2.5 GB
EGAF00002542465 fastq.gz 2.5 GB
EGAF00002542466 fastq.gz 518.5 MB
EGAF00002542467 fastq.gz 520.5 MB
EGAF00002542468 fastq.gz 1.4 GB
EGAF00002542469 fastq.gz 1.4 GB
EGAF00002542470 fastq.gz 4.8 GB
EGAF00002542471 fastq.gz 4.9 GB
EGAF00002542472 fastq.gz 519.8 MB
EGAF00002542473 fastq.gz 524.0 MB
EGAF00002542474 fastq.gz 1.4 GB
EGAF00002542475 fastq.gz 1.4 GB
EGAF00002542476 fastq.gz 4.9 GB
EGAF00002542477 fastq.gz 5.0 GB
EGAF00002542478 fastq.gz 458.3 MB
EGAF00002542479 fastq.gz 458.9 MB
EGAF00002542480 fastq.gz 1.3 GB
EGAF00002542481 fastq.gz 1.3 GB
EGAF00002542482 fastq.gz 4.3 GB
EGAF00002542483 fastq.gz 4.4 GB
EGAF00002542484 fastq.gz 464.7 MB
EGAF00002542485 fastq.gz 465.3 MB
EGAF00002542486 fastq.gz 1.3 GB
EGAF00002542487 fastq.gz 1.3 GB
EGAF00002542488 fastq.gz 4.4 GB
EGAF00002542489 fastq.gz 4.4 GB
EGAF00002542490 fastq.gz 523.5 MB
EGAF00002542491 fastq.gz 525.8 MB
EGAF00002542492 fastq.gz 1.4 GB
EGAF00002542493 fastq.gz 1.4 GB
EGAF00002542494 fastq.gz 4.9 GB
EGAF00002542495 fastq.gz 5.0 GB
EGAF00002542496 fastq.gz 514.6 MB
EGAF00002542497 fastq.gz 514.3 MB
EGAF00002542498 fastq.gz 1.4 GB
EGAF00002542499 fastq.gz 1.4 GB
EGAF00002542500 fastq.gz 4.9 GB
EGAF00002542501 fastq.gz 4.9 GB
EGAF00002542502 fastq.gz 514.4 MB
EGAF00002542503 fastq.gz 513.4 MB
EGAF00002542504 fastq.gz 1.4 GB
EGAF00002542505 fastq.gz 1.4 GB
EGAF00002542506 fastq.gz 4.9 GB
EGAF00002542507 fastq.gz 4.9 GB
EGAF00002542508 fastq.gz 490.9 MB
EGAF00002542509 fastq.gz 490.0 MB
EGAF00002542510 fastq.gz 1.4 GB
EGAF00002542511 fastq.gz 1.4 GB
EGAF00002542512 fastq.gz 4.9 GB
EGAF00002542513 fastq.gz 4.9 GB
EGAF00002542514 fastq.gz 405.7 MB
EGAF00002542515 fastq.gz 406.6 MB
EGAF00002542516 fastq.gz 1.1 GB
EGAF00002542517 fastq.gz 1.1 GB
EGAF00002542518 fastq.gz 3.8 GB
EGAF00002542519 fastq.gz 3.8 GB
EGAF00002542520 fastq.gz 499.3 MB
EGAF00002542521 fastq.gz 498.9 MB
EGAF00002542522 fastq.gz 1.4 GB
EGAF00002542523 fastq.gz 1.4 GB
EGAF00002542524 fastq.gz 4.8 GB
EGAF00002542525 fastq.gz 4.8 GB
EGAF00002542526 fastq.gz 479.4 MB
EGAF00002542527 fastq.gz 473.9 MB
EGAF00002542528 fastq.gz 1.3 GB
EGAF00002542529 fastq.gz 1.3 GB
EGAF00002542530 fastq.gz 4.5 GB
EGAF00002542531 fastq.gz 4.4 GB
EGAF00002542532 fastq.gz 479.5 MB
EGAF00002542533 fastq.gz 473.4 MB
EGAF00002542534 fastq.gz 1.3 GB
EGAF00002542535 fastq.gz 1.3 GB
EGAF00002542536 fastq.gz 4.5 GB
EGAF00002542537 fastq.gz 4.4 GB
EGAF00002542538 fastq.gz 492.2 MB
EGAF00002542539 fastq.gz 485.9 MB
EGAF00002542540 fastq.gz 1.4 GB
EGAF00002542541 fastq.gz 1.4 GB
EGAF00002542542 fastq.gz 4.7 GB
EGAF00002542543 fastq.gz 4.6 GB
EGAF00002542544 fastq.gz 536.3 MB
EGAF00002542545 fastq.gz 529.7 MB
EGAF00002542546 fastq.gz 1.5 GB
EGAF00002542547 fastq.gz 1.5 GB
EGAF00002542548 fastq.gz 5.1 GB
EGAF00002542549 fastq.gz 5.1 GB
EGAF00002542550 fastq.gz 486.3 MB
EGAF00002542551 fastq.gz 480.1 MB
EGAF00002542552 fastq.gz 1.4 GB
EGAF00002542553 fastq.gz 1.3 GB
EGAF00002542554 fastq.gz 4.6 GB
EGAF00002542555 fastq.gz 4.6 GB
EGAF00002542556 fastq.gz 526.4 MB
EGAF00002542557 fastq.gz 525.9 MB
EGAF00002542558 fastq.gz 1.4 GB
EGAF00002542559 fastq.gz 1.4 GB
EGAF00002542560 fastq.gz 5.0 GB
EGAF00002542561 fastq.gz 5.0 GB
EGAF00002542562 fastq.gz 442.1 MB
EGAF00002542563 fastq.gz 443.2 MB
EGAF00002542564 fastq.gz 1.2 GB
EGAF00002542565 fastq.gz 1.2 GB
EGAF00002542566 fastq.gz 4.3 GB
EGAF00002542567 fastq.gz 4.2 GB
EGAF00002542568 fastq.gz 509.8 MB
EGAF00002542569 fastq.gz 511.3 MB
EGAF00002542570 fastq.gz 1.4 GB
EGAF00002542571 fastq.gz 1.4 GB
EGAF00002542572 fastq.gz 4.9 GB
EGAF00002542573 fastq.gz 4.9 GB
EGAF00002542574 fastq.gz 421.9 MB
EGAF00002542575 fastq.gz 423.3 MB
EGAF00002542576 fastq.gz 1.2 GB
EGAF00002542577 fastq.gz 1.2 GB
EGAF00002542578 fastq.gz 3.9 GB
EGAF00002542579 fastq.gz 3.9 GB
EGAF00002542580 fastq.gz 472.6 MB
EGAF00002542581 fastq.gz 471.3 MB
EGAF00002542582 fastq.gz 1.3 GB
EGAF00002542583 fastq.gz 1.3 GB
EGAF00002542584 fastq.gz 4.5 GB
EGAF00002542585 fastq.gz 4.5 GB
EGAF00002542586 fastq.gz 671.1 MB
EGAF00002542587 fastq.gz 684.1 MB
EGAF00002542588 fastq.gz 1.8 GB
EGAF00002542589 fastq.gz 1.8 GB
EGAF00002542590 fastq.gz 6.7 GB
EGAF00002542591 fastq.gz 6.9 GB
EGAF00002542592 fastq.gz 695.6 MB
EGAF00002542593 fastq.gz 712.2 MB
EGAF00002542594 fastq.gz 1.8 GB
EGAF00002542595 fastq.gz 1.9 GB
EGAF00002542596 fastq.gz 6.8 GB
EGAF00002542597 fastq.gz 7.0 GB
EGAF00002542598 fastq.gz 676.2 MB
EGAF00002542599 fastq.gz 686.5 MB
EGAF00002542600 fastq.gz 1.8 GB
EGAF00002542601 fastq.gz 1.9 GB
EGAF00002542602 fastq.gz 6.6 GB
EGAF00002542603 fastq.gz 6.8 GB
EGAF00002542604 fastq.gz 656.5 MB
EGAF00002542605 fastq.gz 656.1 MB
EGAF00002542606 fastq.gz 1.8 GB
EGAF00002542607 fastq.gz 1.8 GB
EGAF00002542608 fastq.gz 6.5 GB
EGAF00002542609 fastq.gz 6.5 GB
EGAF00002542610 fastq.gz 634.7 MB
EGAF00002542611 fastq.gz 637.1 MB
EGAF00002542612 fastq.gz 1.7 GB
EGAF00002542613 fastq.gz 1.7 GB
EGAF00002542614 fastq.gz 6.5 GB
EGAF00002542615 fastq.gz 6.5 GB
EGAF00002542616 fastq.gz 660.2 MB
EGAF00002542617 fastq.gz 659.5 MB
EGAF00002542618 fastq.gz 1.8 GB
EGAF00002542619 fastq.gz 1.8 GB
EGAF00002542620 fastq.gz 6.7 GB
EGAF00002542621 fastq.gz 6.6 GB
EGAF00002542622 fastq.gz 735.5 MB
EGAF00002542623 fastq.gz 736.0 MB
EGAF00002542624 fastq.gz 2.0 GB
EGAF00002542625 fastq.gz 2.0 GB
EGAF00002542626 fastq.gz 7.4 GB
EGAF00002542627 fastq.gz 7.4 GB
EGAF00002542628 fastq.gz 764.9 MB
EGAF00002542629 fastq.gz 767.0 MB
EGAF00002542630 fastq.gz 2.1 GB
EGAF00002542631 fastq.gz 2.1 GB
EGAF00002542632 fastq.gz 7.9 GB
EGAF00002542633 fastq.gz 8.0 GB
EGAF00002542634 fastq.gz 877.2 MB
EGAF00002542635 fastq.gz 882.6 MB
EGAF00002542636 fastq.gz 2.4 GB
EGAF00002542637 fastq.gz 2.4 GB
EGAF00002542638 fastq.gz 9.1 GB
EGAF00002542639 fastq.gz 9.2 GB
EGAF00002542640 fastq.gz 987.0 MB
EGAF00002542641 fastq.gz 991.6 MB
EGAF00002542642 fastq.gz 2.7 GB
EGAF00002542643 fastq.gz 2.7 GB
EGAF00002542644 fastq.gz 9.8 GB
EGAF00002542645 fastq.gz 9.9 GB
EGAF00002542646 fastq.gz 843.1 MB
EGAF00002542647 fastq.gz 836.9 MB
EGAF00002542648 fastq.gz 2.4 GB
EGAF00002542649 fastq.gz 2.3 GB
EGAF00002542650 fastq.gz 8.8 GB
EGAF00002542651 fastq.gz 8.9 GB
EGAF00002542652 fastq.gz 887.7 MB
EGAF00002542653 fastq.gz 878.1 MB
EGAF00002542654 fastq.gz 2.4 GB
EGAF00002542655 fastq.gz 2.4 GB
EGAF00002542656 fastq.gz 9.0 GB
EGAF00002542657 fastq.gz 9.0 GB
EGAF00002542658 fastq.gz 902.3 MB
EGAF00002542659 fastq.gz 892.1 MB
EGAF00002542660 fastq.gz 9.1 GB
EGAF00002542661 fastq.gz 9.1 GB
198 Files (536.2 GB)