Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer
Genomic and transcriptomic data from a cohort of 35 RAS wild-type colorectal cancers. All 35 cases were DNA sequenced at baseline (BL) before treatment with single agent cetuximab. Progressive disease (PD)-biopsies were taken shortly after radiological progression and successfully exome sequenced from 24/35 cases. mRNA sequencing is available for 25 Baseline and 15 PD samples. ctDNA from 9 cases that progressed after prolonged cetuximab benefit were also deep sequenced.
- 155 samples
- DAC: EGAC00001001092
- Technologies: HiSeq X Ten, Illumina HiSeq 2000, Illumina HiSeq 2500
Access to data will be granted to qualified researchers for academic/non-commercial research use subject to signing a data transfer agreement which restricts publication and dissemination of the the dataset and which prohibits any attempt to re-identify any of the study patients. If you need to request access to this data set, please contact: Translational Oncogenomics Lab - Data Access Committee marco.gerlinger@icr.ac.uk
Access to data will be granted to qualified researchers for academic/non-commercial research use subject to signing a data transfer agreement which restricts publication and dissemination of the the dataset and which prohibits any attempt to re-identify any of the study patients. If you need to request access to this data set, please contact: Translational Oncogenomics Lab - Data Access Committee marco.gerlinger@icr.ac.uk
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001003367 | Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00002273524 | bam | 8.0 GB | ||
| EGAF00002273525 | bam | 8.4 GB | ||
| EGAF00002273526 | bam | 8.1 GB | ||
| EGAF00002273527 | bam | 10.7 GB | ||
| EGAF00002273528 | bam | 7.8 GB | ||
| EGAF00002273529 | bam | 9.3 GB | ||
| EGAF00002273530 | bam | 8.7 GB | ||
| EGAF00002273531 | bam | 10.3 GB | ||
| EGAF00002273532 | bam | 8.0 GB | ||
| EGAF00002273533 | bam | 9.8 GB | ||
| EGAF00002273534 | bam | 10.0 GB | ||
| EGAF00002273535 | bam | 8.7 GB | ||
| EGAF00002273536 | bam | 7.8 GB | ||
| EGAF00002273537 | bam | 5.3 GB | ||
| EGAF00002273538 | bam | 5.2 GB | ||
| EGAF00002273539 | bam | 4.9 GB | ||
| EGAF00002273540 | bam | 8.2 GB | ||
| EGAF00002273541 | bam | 6.6 GB | ||
| EGAF00002273542 | bam | 6.7 GB | ||
| EGAF00002273543 | bam | 5.6 GB | ||
| EGAF00002273544 | bam | 5.8 GB | ||
| EGAF00002273545 | bam | 6.9 GB | ||
| EGAF00002273546 | bam | 8.3 GB | ||
| EGAF00002273547 | bam | 5.5 GB | ||
| EGAF00002273548 | bam | 5.8 GB | ||
| EGAF00002273549 | bam | 7.0 GB | ||
| EGAF00002273550 | bam | 6.2 GB | ||
| EGAF00002273551 | bam | 5.9 GB | ||
| EGAF00002273552 | bam | 7.2 GB | ||
| EGAF00002273553 | bam | 6.1 GB | ||
| EGAF00002273554 | bam | 6.9 GB | ||
| EGAF00002273555 | bam | 7.7 GB | ||
| EGAF00002273556 | bam | 8.9 GB | ||
| EGAF00002273557 | bam | 5.7 GB | ||
| EGAF00002273558 | bam | 7.4 GB | ||
| EGAF00002273559 | bam | 5.2 GB | ||
| EGAF00002273560 | bam | 7.8 GB | ||
| EGAF00002273561 | bam | 5.1 GB | ||
| EGAF00002273562 | bam | 8.9 GB | ||
| EGAF00002273563 | bam | 6.3 GB | ||
| EGAF00002273564 | bam | 6.9 GB | ||
| EGAF00002273565 | bam | 7.9 GB | ||
| EGAF00002273566 | bam | 5.6 GB | ||
| EGAF00002273567 | bam | 5.7 GB | ||
| EGAF00002273568 | bam | 5.7 GB | ||
| EGAF00002273569 | bam | 5.8 GB | ||
| EGAF00002273570 | bam | 5.2 GB | ||
| EGAF00002273571 | bam | 6.8 GB | ||
| EGAF00002273572 | bam | 5.5 GB | ||
| EGAF00002273573 | bam | 4.0 GB | ||
| EGAF00002273574 | bam | 7.3 GB | ||
| EGAF00002273575 | bam | 7.7 GB | ||
| EGAF00002273576 | bam | 4.5 GB | ||
| EGAF00002273577 | bam | 4.6 GB | ||
| EGAF00002273578 | bam | 3.4 GB | ||
| EGAF00002273579 | bam | 4.9 GB | ||
| EGAF00002273580 | bam | 4.4 GB | ||
| EGAF00002273581 | bam | 4.6 GB | ||
| EGAF00002273582 | bam | 4.6 GB | ||
| EGAF00002273583 | bam | 4.9 GB | ||
| EGAF00002273584 | bam | 4.5 GB | ||
| EGAF00002273585 | bam | 4.6 GB | ||
| EGAF00002273586 | bam | 4.7 GB | ||
| EGAF00002273587 | bam | 4.9 GB | ||
| EGAF00002273588 | bam | 124.1 GB | ||
| EGAF00002273589 | bam | 52.8 GB | ||
| EGAF00002273590 | bam | 110.6 GB | ||
| EGAF00002273591 | bam | 54.3 GB | ||
| EGAF00002273592 | bam | 100.3 GB | ||
| EGAF00002273593 | bam | 50.9 GB | ||
| EGAF00002273594 | bam | 128.1 GB | ||
| EGAF00002273595 | bam | 63.1 GB | ||
| EGAF00002273596 | bam | 124.8 GB | ||
| EGAF00002273597 | bam | 64.4 GB | ||
| EGAF00002273598 | bam | 118.8 GB | ||
| EGAF00002273599 | bam | 77.3 GB | ||
| EGAF00002273600 | bam | 116.1 GB | ||
| EGAF00002273601 | bam | 64.0 GB | ||
| EGAF00002273602 | bam | 834.0 MB | ||
| EGAF00002273603 | bam | 1.7 GB | ||
| EGAF00002273604 | bam | 1.6 GB | ||
| EGAF00002273605 | bam | 2.2 GB | ||
| EGAF00002273606 | bam | 824.3 MB | ||
| EGAF00002273607 | bam | 1.7 GB | ||
| EGAF00002273608 | bam | 2.5 GB | ||
| EGAF00002273609 | bam | 1.6 GB | ||
| EGAF00002273610 | bam | 2.4 GB | ||
| EGAF00002273611 | bam | 2.9 GB | ||
| EGAF00002273612 | bam | 1.8 GB | ||
| EGAF00002273613 | bam | 2.0 GB | ||
| EGAF00002273614 | bam | 2.1 GB | ||
| EGAF00002273615 | bam | 2.7 GB | ||
| EGAF00002273616 | bam | 1.8 GB | ||
| EGAF00002273617 | bam | 2.8 GB | ||
| EGAF00002273618 | bam | 2.5 GB | ||
| EGAF00002273619 | bam | 2.7 GB | ||
| EGAF00002273620 | bam | 2.6 GB | ||
| EGAF00002273621 | bam | 1.7 GB | ||
| EGAF00002273622 | bam | 2.1 GB | ||
| EGAF00002273623 | bam | 1.6 GB | ||
| EGAF00002273624 | bam | 3.0 GB | ||
| EGAF00002273625 | bam | 2.9 GB | ||
| EGAF00002273626 | bam | 2.3 GB | ||
| EGAF00002273627 | bam | 2.7 GB | ||
| EGAF00002273628 | bam | 1.9 GB | ||
| EGAF00002273629 | bam | 2.8 GB | ||
| EGAF00002273630 | bam | 1.7 GB | ||
| EGAF00002273631 | bam | 3.0 GB | ||
| EGAF00002273632 | bam | 2.7 GB | ||
| EGAF00002273633 | bam | 1.9 GB | ||
| EGAF00002273634 | bam | 1.6 GB | ||
| EGAF00002273635 | bam | 1.6 GB | ||
| EGAF00002273636 | bam | 2.3 GB | ||
| EGAF00002273637 | bam | 1.8 GB | ||
| EGAF00002273638 | bam | 2.8 GB | ||
| EGAF00002273639 | bam | 2.1 GB | ||
| EGAF00002273640 | bam | 2.0 GB | ||
| EGAF00002273641 | bam | 2.2 GB | ||
| EGAF00002273642 | bam | 1.5 GB | ||
| EGAF00002273643 | bam | 1.4 GB | ||
| EGAF00002273644 | bam | 1.5 GB | ||
| EGAF00002273645 | bam | 1.6 GB | ||
| EGAF00002273646 | bam | 1.9 GB | ||
| EGAF00002273647 | bam | 1.8 GB | ||
| EGAF00002273648 | bam | 1.8 GB | ||
| EGAF00002273649 | bam | 2.0 GB | ||
| EGAF00002273650 | bam | 1.3 GB | ||
| EGAF00002273651 | bam | 1.7 GB | ||
| EGAF00002273652 | bam | 1.7 GB | ||
| EGAF00002273653 | bam | 1.6 GB | ||
| EGAF00002273654 | bam | 1.4 GB | ||
| EGAF00002273655 | bam | 1.3 GB | ||
| EGAF00002273656 | bam | 1.6 GB | ||
| EGAF00002273657 | bam | 7.8 GB | ||
| EGAF00002273658 | bam | 8.5 GB | ||
| EGAF00002273659 | bam | 9.2 GB | ||
| EGAF00002273660 | bam | 15.9 GB | ||
| EGAF00002273661 | bam | 8.5 GB | ||
| EGAF00002273662 | bam | 19.3 GB | ||
| EGAF00002273663 | bam | 8.7 GB | ||
| EGAF00002273664 | bam | 15.8 GB | ||
| EGAF00002273665 | bam | 9.5 GB | ||
| EGAF00002273666 | bam | 15.6 GB | ||
| EGAF00002273667 | bam | 15.3 GB | ||
| EGAF00002273668 | bam | 8.8 GB | ||
| EGAF00002273669 | bam | 8.5 GB | ||
| EGAF00002273670 | bam | 13.5 GB | ||
| EGAF00002273671 | bam | 14.1 GB | ||
| EGAF00002273672 | bam | 9.9 GB | ||
| EGAF00002273673 | bam | 9.6 GB | ||
| EGAF00002273674 | bam | 9.3 GB | ||
| EGAF00002273675 | bam | 9.4 GB | ||
| EGAF00002273676 | bam | 8.8 GB | ||
| EGAF00002273677 | bam | 7.9 GB | ||
| EGAF00002273678 | bam | 10.5 GB | ||
| 155 Files (2.0 TB) | ||||