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microRNA-seq of human serum from a longitudinal study of 66 women with no history of cancer

This dataset includes microRNA sequencing data from 198 human serum samples, representing a subset of 66 women with no history of cancer who participated in the UKCTOCS study and with serum samples collected at three timepoints over a period of up to 5 years. Small RNA libraries prepared from the serum samples were sequenced with 50-bp single end reads on an Illumina HiSeq 2000 instrument. Data is provided as FASTQ files.

Request Access

Access to data from the UKCTOCS Longitudinal Women's Cohort (UKLWC) is available by submitting an application to the UKLWC DAC. Access to data will be granted to qualified investigators for appropriate use.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the UK Longitudinal Women’s Cohort grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The UK Longitudinal Women’s Cohort and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. The UK Longitudinal Women’s Cohort: Gynaecological Cancer Research, MRC Clinical Trials Unit UCL, Institute of Clinical Trials & Methodologies, Faculty of Population Health, University College London 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the UK Longitudinal Women’s Cohort within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the UK Longitudinal Women’s Cohort prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the UK Longitudinal Women’s Cohort as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The UK Longitudinal Women’s Cohort may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the UK Longitudinal Women’s Cohort. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. Agreed for User Institution Signature:   Name:   Title:   Date:   Principal Investigator I confirm that I have read and understood this Agreement. Signature:   Name:   Title:   Date:   Agreed for the UK Longitudinal Women’s Cohort Signature:   Name:   Title:   Date:   APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS Dataset reference (EGA Study ID and Dataset Details) EGAXXXXXXXXXXXXX - microRNA-seq of human serum from a longitudinal study of 66 women with no history of cancer This dataset includes microRNA sequencing data from 198 human serum samples, representing a subset of 66 women with no history of cancer who participated in the UKCTOCS study and with serum samples collected at three timepoints over a period of up to 5 years. Small RNA libraries prepared from the serum samples were sequenced with 50-bp single end reads on an Illumina HiSeq 2000 instrument. Data is provided as FASTQ files. Name of project that created the dataset Cancer Research UK – Abcodia Early Diagnosis Consortium Names of other data producers/collaborators UKCTOCS Longitudinal Women’s Cohort, MRC CTU, Institute of Clinical Trials & Methodologies, University College London Division of Cancer, Department of Surgery and Cancer, Imperial College London Cancer Research UK Abcodia Ltd. Specific limitations on areas of research Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY The UK Longitudinal Women’s Cohort intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The UK Longitudinal Women’s Cohort anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 12 months after these data were first made available on the relevant hosting database, unless the UK Longitudinal Women’s Cohort has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with the UK Longitudinal Women’s Cohort.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002167533 fastq.gz 168.0 MB
EGAF00002167534 fastq.gz 173.2 MB
EGAF00002167535 fastq.gz 168.2 MB
EGAF00002167536 fastq.gz 140.0 MB
EGAF00002167537 fastq.gz 135.3 MB
EGAF00002167538 fastq.gz 139.2 MB
EGAF00002167539 fastq.gz 285.2 MB
EGAF00002167540 fastq.gz 267.0 MB
EGAF00002167541 fastq.gz 383.7 MB
EGAF00002167542 fastq.gz 147.9 MB
EGAF00002167543 fastq.gz 141.7 MB
EGAF00002167544 fastq.gz 164.1 MB
EGAF00002167545 fastq.gz 179.6 MB
EGAF00002167546 fastq.gz 177.4 MB
EGAF00002167547 fastq.gz 176.5 MB
EGAF00002167548 fastq.gz 284.5 MB
EGAF00002167549 fastq.gz 209.2 MB
EGAF00002167550 fastq.gz 137.8 MB
EGAF00002167551 fastq.gz 150.6 MB
EGAF00002167552 fastq.gz 172.7 MB
EGAF00002167553 fastq.gz 211.6 MB
EGAF00002167554 fastq.gz 192.2 MB
EGAF00002167555 fastq.gz 214.7 MB
EGAF00002167556 fastq.gz 281.3 MB
EGAF00002167557 fastq.gz 240.7 MB
EGAF00002167558 fastq.gz 165.1 MB
EGAF00002167559 fastq.gz 161.8 MB
EGAF00002167560 fastq.gz 173.1 MB
EGAF00002167561 fastq.gz 186.4 MB
EGAF00002167562 fastq.gz 181.4 MB
EGAF00002167563 fastq.gz 188.6 MB
EGAF00002167564 fastq.gz 193.4 MB
EGAF00002167565 fastq.gz 302.1 MB
EGAF00002167566 fastq.gz 321.0 MB
EGAF00002167567 fastq.gz 214.0 MB
EGAF00002167568 fastq.gz 291.3 MB
EGAF00002167569 fastq.gz 173.8 MB
EGAF00002167570 fastq.gz 163.5 MB
EGAF00002167571 fastq.gz 137.6 MB
EGAF00002167572 fastq.gz 227.8 MB
EGAF00002167573 fastq.gz 166.0 MB
EGAF00002167574 fastq.gz 163.4 MB
EGAF00002167575 fastq.gz 160.1 MB
EGAF00002167576 fastq.gz 164.2 MB
EGAF00002167577 fastq.gz 229.8 MB
EGAF00002167578 fastq.gz 158.3 MB
EGAF00002167579 fastq.gz 143.2 MB
EGAF00002167580 fastq.gz 156.5 MB
EGAF00002167581 fastq.gz 157.0 MB
EGAF00002167582 fastq.gz 193.5 MB
EGAF00002167583 fastq.gz 155.3 MB
EGAF00002167584 fastq.gz 149.8 MB
EGAF00002167585 fastq.gz 156.6 MB
EGAF00002167586 fastq.gz 148.1 MB
EGAF00002167587 fastq.gz 225.3 MB
EGAF00002167588 fastq.gz 199.0 MB
EGAF00002167589 fastq.gz 158.5 MB
EGAF00002167590 fastq.gz 177.4 MB
EGAF00002167591 fastq.gz 190.1 MB
EGAF00002167592 fastq.gz 265.7 MB
EGAF00002167593 fastq.gz 164.4 MB
EGAF00002167594 fastq.gz 204.3 MB
EGAF00002167595 fastq.gz 201.7 MB
EGAF00002167596 fastq.gz 184.9 MB
EGAF00002167597 fastq.gz 180.7 MB
EGAF00002167598 fastq.gz 168.5 MB
EGAF00002167599 fastq.gz 144.2 MB
EGAF00002167600 fastq.gz 183.0 MB
EGAF00002167601 fastq.gz 130.6 MB
EGAF00002167602 fastq.gz 134.6 MB
EGAF00002167603 fastq.gz 287.7 MB
EGAF00002167604 fastq.gz 142.3 MB
EGAF00002167605 fastq.gz 181.2 MB
EGAF00002167606 fastq.gz 224.8 MB
EGAF00002167607 fastq.gz 170.0 MB
EGAF00002167608 fastq.gz 152.9 MB
EGAF00002167609 fastq.gz 213.9 MB
EGAF00002167610 fastq.gz 327.0 MB
EGAF00002167611 fastq.gz 214.1 MB
EGAF00002167612 fastq.gz 290.3 MB
EGAF00002167613 fastq.gz 164.1 MB
EGAF00002167614 fastq.gz 388.5 MB
EGAF00002167615 fastq.gz 175.9 MB
EGAF00002167616 fastq.gz 152.7 MB
EGAF00002167617 fastq.gz 172.1 MB
EGAF00002167618 fastq.gz 196.8 MB
EGAF00002167619 fastq.gz 184.5 MB
EGAF00002167620 fastq.gz 186.3 MB
EGAF00002167621 fastq.gz 212.9 MB
EGAF00002167622 fastq.gz 203.7 MB
EGAF00002167623 fastq.gz 148.8 MB
EGAF00002167624 fastq.gz 165.8 MB
EGAF00002167625 fastq.gz 166.7 MB
EGAF00002167626 fastq.gz 194.6 MB
EGAF00002167627 fastq.gz 144.4 MB
EGAF00002167628 fastq.gz 225.9 MB
EGAF00002167629 fastq.gz 179.3 MB
EGAF00002167630 fastq.gz 204.2 MB
EGAF00002167631 fastq.gz 194.5 MB
EGAF00002167632 fastq.gz 127.5 MB
EGAF00002167633 fastq.gz 184.6 MB
EGAF00002167634 fastq.gz 182.0 MB
EGAF00002167635 fastq.gz 185.7 MB
EGAF00002167636 fastq.gz 400.4 MB
EGAF00002167637 fastq.gz 198.1 MB
EGAF00002167638 fastq.gz 141.8 MB
EGAF00002167639 fastq.gz 181.5 MB
EGAF00002167640 fastq.gz 153.3 MB
EGAF00002167641 fastq.gz 130.8 MB
EGAF00002167642 fastq.gz 185.7 MB
EGAF00002167643 fastq.gz 172.8 MB
EGAF00002167644 fastq.gz 242.6 MB
EGAF00002167645 fastq.gz 171.4 MB
EGAF00002167646 fastq.gz 262.3 MB
EGAF00002167647 fastq.gz 131.5 MB
EGAF00002167648 fastq.gz 156.9 MB
EGAF00002167649 fastq.gz 181.9 MB
EGAF00002167650 fastq.gz 127.9 MB
EGAF00002167651 fastq.gz 206.5 MB
EGAF00002167652 fastq.gz 164.0 MB
EGAF00002167653 fastq.gz 177.5 MB
EGAF00002167654 fastq.gz 192.7 MB
EGAF00002167655 fastq.gz 163.4 MB
EGAF00002167656 fastq.gz 167.4 MB
EGAF00002167657 fastq.gz 207.6 MB
EGAF00002167658 fastq.gz 187.2 MB
EGAF00002167659 fastq.gz 171.5 MB
EGAF00002167660 fastq.gz 184.7 MB
EGAF00002167661 fastq.gz 214.7 MB
EGAF00002167662 fastq.gz 205.6 MB
EGAF00002167663 fastq.gz 179.9 MB
EGAF00002167664 fastq.gz 218.2 MB
EGAF00002167665 fastq.gz 130.0 MB
EGAF00002167666 fastq.gz 176.8 MB
EGAF00002167667 fastq.gz 141.4 MB
EGAF00002167668 fastq.gz 175.3 MB
EGAF00002167669 fastq.gz 218.5 MB
EGAF00002167670 fastq.gz 165.5 MB
EGAF00002167671 fastq.gz 161.6 MB
EGAF00002167672 fastq.gz 172.5 MB
EGAF00002167673 fastq.gz 174.8 MB
EGAF00002167674 fastq.gz 236.7 MB
EGAF00002167675 fastq.gz 138.6 MB
EGAF00002167676 fastq.gz 141.3 MB
EGAF00002167677 fastq.gz 166.8 MB
EGAF00002167678 fastq.gz 209.6 MB
EGAF00002167679 fastq.gz 188.0 MB
EGAF00002167680 fastq.gz 226.5 MB
EGAF00002167681 fastq.gz 314.6 MB
EGAF00002167682 fastq.gz 362.4 MB
EGAF00002167683 fastq.gz 144.6 MB
EGAF00002167684 fastq.gz 175.8 MB
EGAF00002167685 fastq.gz 144.7 MB
EGAF00002167686 fastq.gz 165.2 MB
EGAF00002167687 fastq.gz 182.3 MB
EGAF00002167688 fastq.gz 128.3 MB
EGAF00002167689 fastq.gz 159.9 MB
EGAF00002167690 fastq.gz 236.5 MB
EGAF00002167691 fastq.gz 186.1 MB
EGAF00002167692 fastq.gz 133.8 MB
EGAF00002167693 fastq.gz 148.7 MB
EGAF00002167694 fastq.gz 154.9 MB
EGAF00002167695 fastq.gz 152.1 MB
EGAF00002167696 fastq.gz 159.4 MB
EGAF00002167697 fastq.gz 158.2 MB
EGAF00002167698 fastq.gz 189.6 MB
EGAF00002167699 fastq.gz 172.5 MB
EGAF00002167700 fastq.gz 211.0 MB
EGAF00002167701 fastq.gz 198.3 MB
EGAF00002167702 fastq.gz 192.4 MB
EGAF00002167703 fastq.gz 198.2 MB
EGAF00002167704 fastq.gz 256.1 MB
EGAF00002167705 fastq.gz 180.0 MB
EGAF00002167706 fastq.gz 166.7 MB
EGAF00002167707 fastq.gz 189.7 MB
EGAF00002167708 fastq.gz 167.4 MB
EGAF00002167709 fastq.gz 212.3 MB
EGAF00002167710 fastq.gz 243.2 MB
EGAF00002167711 fastq.gz 245.2 MB
EGAF00002167712 fastq.gz 321.6 MB
EGAF00002167713 fastq.gz 138.0 MB
EGAF00002167714 fastq.gz 156.0 MB
EGAF00002167715 fastq.gz 142.5 MB
EGAF00002167716 fastq.gz 190.8 MB
EGAF00002167717 fastq.gz 171.6 MB
EGAF00002167718 fastq.gz 202.5 MB
EGAF00002167719 fastq.gz 211.8 MB
EGAF00002167720 fastq.gz 283.2 MB
EGAF00002167721 fastq.gz 266.8 MB
EGAF00002167722 fastq.gz 405.5 MB
EGAF00002167723 fastq.gz 415.5 MB
EGAF00002167724 fastq.gz 190.9 MB
EGAF00002167725 fastq.gz 197.5 MB
EGAF00002167726 fastq.gz 159.0 MB
EGAF00002167727 fastq.gz 163.6 MB
EGAF00002167728 fastq.gz 183.0 MB
EGAF00002167729 fastq.gz 133.2 MB
EGAF00002167730 fastq.gz 156.0 MB
198 Files (38.1 GB)