Adenoma development in familial adenomatous polyposis and MUTYH‐associated polyposis: somatic landscape and driver genes
Familial adenomatous polyposis (FAP) and MUTYH‐associated polyposis (MAP) are inherited disorders associated with multiple colorectal adenomas that lead to a very high risk of colorectal cancer. The somatic mutations that drive adenoma development in these conditions have not been investigated comprehensively. In this study we performed analysis of paired colorectal adenoma and normal tissue DNA from individuals with FAP or MAP, sequencing 14 adenoma whole exomes (eight MAP, six FAP), 55 adenoma targeted exomes (33 MAP, 22 FAP) and germline DNA from each patient.
- 121 samples
- DAC: EGAC00001000205
- Technologies: Illumina Genome Analyzer II, Illumina HiSeq 2000
Wellcome Trust Sanger Institute Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001000044 | Other | |
| EGAS00001000077 | Other | |
| EGAS00001000358 | Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00000071471 | srf | 13.6 GB | ||
| EGAF00000071472 | srf | 23.6 GB | ||
| EGAF00000071473 | srf | 23.0 GB | ||
| EGAF00000071474 | srf | 14.2 GB | ||
| EGAF00000071475 | srf | 22.6 GB | ||
| EGAF00000071476 | srf | 22.0 GB | ||
| EGAF00000071477 | srf | 14.9 GB | ||
| EGAF00000071478 | srf | 22.0 GB | ||
| EGAF00000071479 | srf | 12.7 GB | ||
| EGAF00000071480 | srf | 21.9 GB | ||
| EGAF00000071481 | srf | 11.0 GB | ||
| EGAF00000071482 | srf | 11.4 GB | ||
| EGAF00000071483 | srf | 16.5 GB | ||
| EGAF00000071484 | srf | 13.8 GB | ||
| EGAF00000071485 | srf | 20.0 GB | ||
| EGAF00000071486 | srf | 14.0 GB | ||
| EGAF00000071487 | srf | 18.9 GB | ||
| EGAF00000071488 | srf | 13.3 GB | ||
| EGAF00000071489 | srf | 13.1 GB | ||
| EGAF00000071490 | srf | 22.8 GB | ||
| EGAF00000071491 | srf | 21.5 GB | ||
| EGAF00000071492 | srf | 22.7 GB | ||
| EGAF00000071493 | srf | 11.4 GB | ||
| EGAF00000071494 | srf | 14.2 GB | ||
| EGAF00000071495 | srf | 14.0 GB | ||
| EGAF00000071496 | srf | 12.6 GB | ||
| EGAF00000071497 | srf | 17.0 GB | ||
| EGAF00000071498 | srf | 20.2 GB | ||
| EGAF00000071499 | srf | 20.1 GB | ||
| EGAF00000071500 | srf | 20.0 GB | ||
| EGAF00000071501 | srf | 19.8 GB | ||
| EGAF00000071502 | srf | 20.4 GB | ||
| EGAF00000071503 | srf | 14.3 GB | ||
| EGAF00000071504 | srf | 21.1 GB | ||
| EGAF00000071505 | srf | 21.3 GB | ||
| EGAF00000071506 | srf | 2.0 GB | ||
| EGAF00000071507 | srf | 19.9 GB | ||
| EGAF00000071508 | srf | 14.8 GB | ||
| EGAF00000071509 | srf | 19.7 GB | ||
| EGAF00000071510 | srf | 13.4 GB | ||
| EGAF00000071511 | srf | 10.8 GB | ||
| EGAF00000071512 | srf | 20.3 GB | ||
| EGAF00000071513 | srf | 16.7 GB | ||
| EGAF00000071514 | srf | 12.6 GB | ||
| EGAF00000071515 | srf | 11.2 GB | ||
| EGAF00000071516 | srf | 17.1 GB | ||
| EGAF00000071517 | srf | 17.4 GB | ||
| EGAF00000071518 | srf | 20.4 GB | ||
| EGAF00000071519 | srf | 20.2 GB | ||
| EGAF00000071520 | srf | 20.9 GB | ||
| EGAF00000071521 | srf | 20.3 GB | ||
| EGAF00000071522 | srf | 12.2 GB | ||
| EGAF00000071523 | srf | 13.6 GB | ||
| EGAF00000071524 | srf | 13.9 GB | ||
| EGAF00000071525 | srf | 11.8 GB | ||
| EGAF00000071526 | srf | 13.8 GB | ||
| EGAF00000071527 | srf | 26.3 GB | ||
| EGAF00000071528 | srf | 26.2 GB | ||
| EGAF00000071529 | srf | 26.6 GB | ||
| EGAF00000071530 | srf | 9.6 GB | ||
| EGAF00000071531 | srf | 14.4 GB | ||
| EGAF00000071532 | srf | 22.6 GB | ||
| EGAF00000071533 | srf | 24.9 GB | ||
| EGAF00000071534 | srf | 24.4 GB | ||
| EGAF00000071535 | srf | 13.8 GB | ||
| EGAF00000071536 | srf | 13.3 GB | ||
| EGAF00000071537 | srf | 16.4 GB | ||
| EGAF00000071538 | srf | 13.2 GB | ||
| EGAF00000071539 | srf | 11.6 GB | ||
| EGAF00000071540 | srf | 12.7 GB | ||
| EGAF00000096628 | bam | 2.0 GB | ||
| EGAF00000096629 | bam | 1.7 GB | ||
| EGAF00000096630 | bam | 2.0 GB | ||
| EGAF00000096631 | bam | 1.9 GB | ||
| EGAF00000096632 | bam | 1.8 GB | ||
| EGAF00000096633 | bam | 1.6 GB | ||
| EGAF00000096634 | bam | 1.6 GB | ||
| EGAF00000096635 | bam | 1.6 GB | ||
| EGAF00000096636 | bam | 1.6 GB | ||
| EGAF00000096637 | bam | 1.6 GB | ||
| EGAF00000096638 | bam | 1.8 GB | ||
| EGAF00000096639 | bam | 1.8 GB | ||
| EGAF00000096640 | bam | 1.9 GB | ||
| EGAF00000096641 | bam | 1.9 GB | ||
| EGAF00000096642 | bam | 1.8 GB | ||
| EGAF00000096643 | bam | 1.8 GB | ||
| EGAF00000096644 | bam | 1.5 GB | ||
| EGAF00000096645 | bam | 1.7 GB | ||
| EGAF00000096646 | bam | 1.6 GB | ||
| EGAF00000096647 | bam | 1.7 GB | ||
| EGAF00000096648 | bam | 1.6 GB | ||
| EGAF00000096649 | bam | 1.5 GB | ||
| EGAF00000096650 | bam | 1.6 GB | ||
| EGAF00000096651 | bam | 1.4 GB | ||
| EGAF00000096652 | bam | 1.7 GB | ||
| EGAF00000096653 | bam | 1.7 GB | ||
| EGAF00000096654 | bam | 1.7 GB | ||
| EGAF00000096655 | bam | 1.7 GB | ||
| EGAF00000096656 | bam | 1.7 GB | ||
| EGAF00000096657 | bam | 1.6 GB | ||
| EGAF00000096658 | bam | 1.5 GB | ||
| EGAF00000096659 | bam | 1.6 GB | ||
| EGAF00000096660 | bam | 1.4 GB | ||
| EGAF00000096661 | bam | 1.3 GB | ||
| EGAF00000096662 | bam | 1.5 GB | ||
| EGAF00000096663 | bam | 1.5 GB | ||
| EGAF00000096664 | bam | 1.9 GB | ||
| EGAF00000096665 | bam | 2.0 GB | ||
| EGAF00000096666 | bam | 2.1 GB | ||
| EGAF00000096667 | bam | 2.0 GB | ||
| EGAF00000096668 | bam | 1.8 GB | ||
| EGAF00000096669 | bam | 1.7 GB | ||
| EGAF00000096670 | bam | 1.6 GB | ||
| EGAF00000096671 | bam | 1.7 GB | ||
| EGAF00000096672 | bam | 1.7 GB | ||
| EGAF00000096673 | bam | 1.6 GB | ||
| EGAF00000096674 | bam | 1.7 GB | ||
| EGAF00000096675 | bam | 1.7 GB | ||
| EGAF00000096676 | bam | 1.9 GB | ||
| EGAF00000096677 | bam | 2.0 GB | ||
| EGAF00000096678 | bam | 1.7 GB | ||
| EGAF00000096679 | bam | 1.8 GB | ||
| EGAF00000096680 | bam | 1.8 GB | ||
| EGAF00000096681 | bam | 1.8 GB | ||
| EGAF00000096682 | bam | 1.8 GB | ||
| EGAF00000096683 | bam | 1.8 GB | ||
| EGAF00000096684 | bam | 1.7 GB | ||
| EGAF00000096685 | bam | 1.5 GB | ||
| EGAF00000096686 | bam | 1.6 GB | ||
| EGAF00000096687 | bam | 1.4 GB | ||
| EGAF00000096688 | bam | 2.2 GB | ||
| EGAF00000096689 | bam | 1.9 GB | ||
| EGAF00000096690 | bam | 2.2 GB | ||
| EGAF00000096691 | bam | 2.1 GB | ||
| EGAF00000096692 | bam | 2.0 GB | ||
| EGAF00000096693 | bam | 2.0 GB | ||
| EGAF00000096694 | bam | 1.8 GB | ||
| EGAF00000096695 | bam | 1.9 GB | ||
| EGAF00000096696 | bam | 1.7 GB | ||
| EGAF00000096697 | bam | 1.5 GB | ||
| EGAF00000096698 | bam | 1.8 GB | ||
| EGAF00000096699 | bam | 1.7 GB | ||
| EGAF00000096700 | bam | 2.1 GB | ||
| EGAF00000096701 | bam | 1.8 GB | ||
| EGAF00000096702 | bam | 1.8 GB | ||
| EGAF00000096703 | bam | 1.8 GB | ||
| EGAF00000096704 | bam | 1.8 GB | ||
| EGAF00000096705 | bam | 1.9 GB | ||
| EGAF00000096706 | bam | 1.8 GB | ||
| EGAF00000096707 | bam | 2.0 GB | ||
| EGAF00000096708 | bam | 1.8 GB | ||
| EGAF00000096709 | bam | 1.6 GB | ||
| EGAF00000096710 | bam | 1.8 GB | ||
| EGAF00000096711 | bam | 1.8 GB | ||
| EGAF00000103254 | bam | 4.9 GB | ||
| EGAF00000108597 | bam | 4.3 GB | ||
| EGAF00000108598 | bam | 4.8 GB | ||
| EGAF00000108599 | bam | 4.6 GB | ||
| EGAF00000108600 | bam | 4.4 GB | ||
| EGAF00000108601 | bam | 4.7 GB | ||
| EGAF00000108602 | bam | 4.7 GB | ||
| EGAF00000108603 | bam | 4.5 GB | ||
| EGAF00000108604 | bam | 4.8 GB | ||
| EGAF00000108605 | bam | 4.1 GB | ||
| EGAF00000108606 | bam | 4.5 GB | ||
| EGAF00000166811 | bam | 10.1 GB | ||
| EGAF00000166812 | bam | 10.1 GB | ||
| EGAF00000166813 | bam | 9.4 GB | ||
| EGAF00000166814 | bam | 9.9 GB | ||
| EGAF00000166815 | bam | 10.2 GB | ||
| EGAF00000166816 | bam | 10.3 GB | ||
| EGAF00000168177 | bam | 7.4 GB | ||
| EGAF00000168178 | bam | 7.2 GB | ||
| EGAF00000168179 | bam | 7.3 GB | ||
| EGAF00000168180 | bam | 7.9 GB | ||
| 175 Files (1.5 TB) | ||||