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The landscape of somatic mutation in normal colorectal epithelial cells

The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic events and consequent clonal expansions leading to cancer. As for most cancer types, however, understanding of the earliest phases of colorectal neoplastic change, which may occur in morphologically normal tissue, is comparatively limited because of the difficulty of detecting somatic mutations in normal cells. Each colorectal crypt is a small clone of cells derived from a single recently-existing stem cell. Here, we sequenced hundreds of normal crypts from 42 individuals. Signatures of multiple mutational processes were revealed, some ubiquitous and continuous, others only found in some individuals, in some crypts or during some phases of the cell lineage from zygote to adult cell. Likely driver mutations were present in ~1% of normal colorectal crypts in middle-aged individuals, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colorectal epithelium.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002027170 cram 41.6 MB
EGAF00002044863 cram 108.7 MB
EGAF00002044864 cram 44.6 MB
EGAF00002044865 cram 109.5 MB
EGAF00002044866 cram 44.9 MB
EGAF00002044867 cram 118.2 MB
EGAF00002044868 cram 56.1 MB
EGAF00002044869 cram 127.3 MB
EGAF00002044870 cram 1.1 MB
EGAF00002044871 cram 99.2 MB
EGAF00002044872 cram 132.3 MB
EGAF00002044873 cram 148.8 MB
EGAF00002044874 cram 145.2 MB
EGAF00002044875 cram 179.2 MB
EGAF00002044876 cram 161.7 MB
EGAF00002044877 cram 155.8 MB
EGAF00002044878 cram 339.7 MB
EGAF00002044879 cram 38.0 MB
EGAF00002044880 cram 63.2 MB
EGAF00002044881 cram 279.8 MB
EGAF00002044882 cram 235.8 MB
EGAF00002044883 cram 32.7 MB
EGAF00002044884 cram 254.7 MB
EGAF00002044885 cram 42.1 MB
EGAF00002044886 cram 42.8 MB
EGAF00002044887 cram 25.7 MB
EGAF00002044888 cram 36.1 MB
EGAF00002044889 cram 34.5 MB
EGAF00002044890 cram 290.7 MB
EGAF00002044891 cram 41.4 MB
EGAF00002044892 cram 199.1 MB
EGAF00002044893 cram 177.7 MB
EGAF00002044894 cram 158.0 MB
EGAF00002044895 cram 189.6 MB
EGAF00002044896 cram 64.7 MB
EGAF00002044897 cram 129.6 MB
EGAF00002044898 cram 196.8 MB
EGAF00002044899 cram 162.2 MB
EGAF00002044900 cram 54.9 MB
EGAF00002044901 cram 149.3 MB
EGAF00002044902 cram 143.3 MB
EGAF00002044903 cram 146.9 MB
EGAF00002044904 cram 150.9 MB
EGAF00002044905 cram 151.4 MB
EGAF00002044906 cram 163.5 MB
EGAF00002044907 cram 147.4 MB
EGAF00002044908 cram 57.1 MB
EGAF00002044909 cram 144.3 MB
EGAF00002044910 cram 157.1 MB
EGAF00002044911 cram 185.0 MB
EGAF00002044912 cram 194.1 MB
EGAF00002044913 cram 159.0 MB
EGAF00002044914 cram 151.3 MB
EGAF00002044915 cram 66.8 MB
EGAF00002044916 cram 143.0 MB
EGAF00002044917 cram 152.9 MB
EGAF00002044918 cram 65.6 MB
EGAF00002044919 cram 174.7 MB
EGAF00002044920 cram 60.4 MB
EGAF00002044921 cram 134.6 MB
EGAF00002044922 cram 13.5 MB
EGAF00002044923 cram 170.9 MB
EGAF00002044924 cram 150.9 MB
EGAF00002044925 cram 162.1 MB
EGAF00002044926 cram 170.8 MB
EGAF00002044927 cram 246.7 MB
EGAF00002044928 cram 277.0 MB
EGAF00002044929 cram 21.6 MB
EGAF00002044930 cram 27.8 MB
EGAF00002044931 cram 288.3 MB
EGAF00002044932 cram 214.3 MB
EGAF00002044933 cram 276.2 MB
EGAF00002044934 cram 198.5 MB
EGAF00002044935 cram 14.8 MB
EGAF00002044936 cram 3.3 MB
EGAF00002044937 cram 148.4 MB
EGAF00002044938 cram 35.2 MB
EGAF00002044939 cram 195.7 MB
EGAF00002044940 cram 273.9 MB
EGAF00002044941 cram 175.5 MB
EGAF00002044942 cram 156.2 MB
EGAF00002044943 cram 167.2 MB
EGAF00002044944 cram 254.1 MB
EGAF00002044945 cram 117.4 MB
EGAF00002044946 cram 105.3 MB
EGAF00002044947 cram 101.2 MB
EGAF00002044948 cram 122.6 MB
EGAF00002044949 cram 134.5 MB
EGAF00002044950 cram 117.2 MB
EGAF00002044951 cram 14.8 MB
EGAF00002044952 cram 111.6 MB
EGAF00002044953 cram 14.1 MB
EGAF00002044954 cram 379.5 MB
EGAF00002044955 cram 98.6 MB
EGAF00002044956 cram 137.9 MB
EGAF00002044957 cram 27.2 MB
EGAF00002044958 cram 123.8 MB
EGAF00002044959 cram 405.2 MB
EGAF00002044960 cram 186.4 MB
EGAF00002044961 cram 104.6 MB
EGAF00002044962 cram 133.5 MB
EGAF00002044963 cram 115.2 MB
EGAF00002044964 cram 22.6 MB
EGAF00002044965 cram 114.4 MB
EGAF00002044966 cram 12.6 MB
EGAF00002044967 cram 170.8 MB
EGAF00002044968 cram 199.6 MB
EGAF00002044969 cram 116.2 MB
EGAF00002044970 cram 168.6 MB
EGAF00002044971 cram 145.0 MB
EGAF00002044972 cram 132.8 MB
EGAF00002044973 cram 224.8 MB
EGAF00002044974 cram 186.8 MB
EGAF00002044975 cram 187.3 MB
EGAF00002044976 cram 193.3 MB
EGAF00002044977 cram 213.3 MB
EGAF00002044978 cram 185.2 MB
EGAF00002044979 cram 50.3 MB
EGAF00002044980 cram 13.4 MB
EGAF00002044981 cram 43.8 MB
EGAF00002044982 cram 62.9 MB
EGAF00002044983 cram 221.6 MB
EGAF00002044984 cram 250.5 MB
EGAF00002044985 cram 290.7 MB
EGAF00002044986 cram 97.1 MB
EGAF00002044987 cram 29.3 MB
EGAF00002044988 cram 48.3 MB
EGAF00002044989 cram 61.6 MB
EGAF00002044990 cram 50.2 MB
EGAF00002044991 cram 358.8 MB
EGAF00002044992 cram 45.9 MB
EGAF00002044993 cram 265.3 MB
EGAF00002044994 cram 411.5 MB
EGAF00002044995 cram 41.7 MB
EGAF00002044996 cram 261.2 MB
EGAF00002044997 cram 306.0 MB
EGAF00002044998 cram 49.5 MB
EGAF00002044999 cram 292.0 MB
EGAF00002045000 cram 25.7 MB
EGAF00002045001 cram 271.2 MB
EGAF00002045002 cram 307.6 MB
EGAF00002045003 cram 250.6 MB
EGAF00002045004 cram 53.7 MB
EGAF00002045005 cram 2.3 MB
EGAF00002045006 cram 195.0 MB
EGAF00002045007 cram 228.9 MB
EGAF00002045008 cram 70.9 MB
EGAF00002045009 cram 66.2 MB
EGAF00002045010 cram 142.0 MB
EGAF00002045011 cram 214.0 MB
EGAF00002045012 cram 140.6 MB
EGAF00002045013 cram 156.2 MB
EGAF00002045014 cram 161.8 MB
EGAF00002045015 cram 159.0 MB
EGAF00002045016 cram 64.6 MB
EGAF00002045017 cram 59.6 MB
EGAF00002045018 cram 212.6 MB
EGAF00002045019 cram 147.7 MB
EGAF00002045020 cram 192.5 MB
EGAF00002045021 cram 189.3 MB
EGAF00002045022 cram 186.9 MB
EGAF00002045023 cram 56.3 MB
EGAF00002045024 cram 49.7 MB
EGAF00002045025 cram 60.7 MB
EGAF00002045026 cram 215.7 MB
EGAF00002045027 cram 168.1 MB
EGAF00002045028 cram 62.3 MB
EGAF00002045029 cram 66.5 MB
EGAF00002045030 cram 231.3 MB
EGAF00002045031 cram 215.9 MB
EGAF00002045032 cram 67.7 MB
EGAF00002045033 cram 226.9 MB
EGAF00002045034 cram 170.8 MB
EGAF00002045035 cram 73.9 MB
EGAF00002045036 cram 100.6 MB
EGAF00002045037 cram 206.2 MB
EGAF00002045038 cram 142.7 MB
EGAF00002045039 cram 153.7 MB
EGAF00002045040 cram 134.5 MB
EGAF00002045041 cram 167.6 MB
EGAF00002045042 cram 165.6 MB
EGAF00002045043 cram 170.2 MB
EGAF00002045044 cram 82.1 MB
EGAF00002045045 cram 153.4 MB
EGAF00002045046 cram 1.5 MB
EGAF00002045047 cram 1.8 MB
EGAF00002045048 cram 177.4 MB
EGAF00002045049 cram 137.5 MB
EGAF00002045050 cram 165.4 MB
EGAF00002045051 cram 130.2 MB
EGAF00002045052 cram 121.5 MB
EGAF00002045053 cram 125.8 MB
EGAF00002045054 cram 187.5 MB
EGAF00002045055 cram 230.0 MB
EGAF00002045056 cram 132.0 MB
EGAF00002045057 cram 166.4 MB
EGAF00002045058 cram 147.9 MB
EGAF00002045059 cram 168.8 MB
EGAF00002045060 cram 132.3 MB
EGAF00002045061 cram 127.6 MB
EGAF00002045062 cram 217.9 MB
EGAF00002045063 cram 126.3 MB
EGAF00002045064 cram 146.9 MB
EGAF00002045065 cram 160.5 MB
EGAF00002045066 cram 95.3 MB
EGAF00002045067 cram 17.6 MB
EGAF00002045068 cram 359.2 MB
EGAF00002045069 cram 1.7 MB
EGAF00002045070 cram 18.5 MB
EGAF00002045071 cram 49.0 MB
EGAF00002045072 cram 35.6 MB
EGAF00002045073 cram 47.8 MB
EGAF00002045074 cram 51.1 MB
EGAF00002045075 cram 53.3 MB
EGAF00002045076 cram 38.7 MB
EGAF00002045077 cram 286.2 MB
EGAF00002045078 cram 37.5 MB
EGAF00002045079 cram 39.3 MB
EGAF00002045080 cram 47.8 MB
EGAF00002045081 cram 43.0 MB
EGAF00002045082 cram 19.2 MB
EGAF00002045083 cram 443.6 MB
EGAF00002045084 cram 53.1 MB
EGAF00002045085 cram 50.6 MB
EGAF00002045086 cram 36.4 MB
EGAF00002045087 cram 246.2 MB
EGAF00002045088 cram 286.1 MB
EGAF00002045089 cram 58.3 MB
EGAF00002045090 cram 22.5 MB
EGAF00002045091 cram 157.9 MB
EGAF00002045092 cram 278.6 MB
EGAF00002045093 cram 51.2 MB
EGAF00002045094 cram 56.3 MB
EGAF00002045095 cram 51.4 MB
EGAF00002045096 cram 441.5 MB
EGAF00002045097 cram 405.6 MB
EGAF00002045098 cram 48.5 MB
EGAF00002045099 cram 335.0 MB
EGAF00002045100 cram 71.6 MB
EGAF00002045101 cram 154.3 MB
EGAF00002045102 cram 152.7 MB
EGAF00002045103 cram 72.3 MB
EGAF00002045104 cram 210.0 MB
EGAF00002045105 cram 70.8 MB
EGAF00002045106 cram 162.9 MB
EGAF00002045107 cram 237.3 MB
EGAF00002045108 cram 220.1 MB
EGAF00002045109 cram 162.1 MB
EGAF00002045110 cram 158.7 MB
EGAF00002045111 cram 165.5 MB
EGAF00002045112 cram 178.1 MB
EGAF00002045113 cram 11.5 MB
EGAF00002045114 cram 32.0 MB
EGAF00002045115 cram 99.5 MB
EGAF00002045116 cram 34.6 MB
EGAF00002045117 cram 9.8 MB
EGAF00002045118 cram 14.2 MB
EGAF00002045119 cram 233.2 MB
EGAF00002045120 cram 201.7 MB
EGAF00002045121 cram 574.7 kB
EGAF00002045122 cram 92.4 MB
EGAF00002045123 cram 50.1 MB
EGAF00002045124 cram 132.2 MB
EGAF00002045125 cram 9.2 MB
EGAF00002045126 cram 124.8 MB
EGAF00002045127 cram 200.7 MB
EGAF00002045128 cram 101.0 MB
EGAF00002045129 cram 106.1 MB
EGAF00002045130 cram 139.3 MB
EGAF00002045131 cram 106.9 MB
EGAF00002045132 cram 104.7 MB
EGAF00002045133 cram 146.5 MB
EGAF00002045134 cram 139.2 MB
EGAF00002045135 cram 153.0 MB
EGAF00002045136 cram 16.8 MB
EGAF00002045137 cram 64.4 MB
EGAF00002045138 cram 110.9 MB
EGAF00002045139 cram 97.9 MB
EGAF00002045140 cram 119.1 MB
EGAF00002045141 cram 148.5 MB
EGAF00002045142 cram 104.0 MB
EGAF00002045143 cram 82.1 MB
EGAF00002045144 cram 80.0 MB
EGAF00002045145 cram 86.5 MB
EGAF00002045146 cram 16.6 MB
EGAF00002045147 cram 91.7 MB
EGAF00002045148 cram 118.3 MB
EGAF00002045149 cram 107.7 MB
EGAF00002045150 cram 76.3 MB
EGAF00002045151 cram 263.4 MB
EGAF00002045152 cram 228.4 MB
EGAF00002045153 cram 85.9 MB
EGAF00002045154 cram 89.1 MB
EGAF00002045155 cram 106.3 MB
EGAF00002045156 cram 25.4 MB
EGAF00002045157 cram 18.6 MB
EGAF00002045158 cram 20.0 MB
EGAF00002045159 cram 378.3 MB
EGAF00002045160 cram 77.9 MB
EGAF00002045161 cram 19.7 MB
EGAF00002045162 cram 16.7 MB
EGAF00002045163 cram 119.2 MB
EGAF00002045164 cram 24.4 MB
EGAF00002045165 cram 18.8 MB
EGAF00002045166 cram 18.8 MB
EGAF00002045167 cram 125.8 MB
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EGAF00002045169 cram 118.2 MB
EGAF00002045170 cram 419.9 MB
EGAF00002045171 cram 27.5 MB
EGAF00002045172 cram 26.8 MB
EGAF00002045173 cram 165.5 MB
EGAF00002045174 cram 84.6 MB
EGAF00002045175 cram 119.0 MB
EGAF00002045176 cram 20.0 MB
EGAF00002045177 cram 2.8 MB
EGAF00002045178 cram 124.3 MB
EGAF00002045179 cram 128.9 MB
EGAF00002045180 cram 170.3 MB
EGAF00002045181 cram 212.3 MB
EGAF00002045182 cram 20.3 MB
EGAF00002045183 cram 177.2 MB
EGAF00002045184 cram 9.8 MB
EGAF00002045185 cram 6.8 MB
EGAF00002045186 cram 7.1 MB
EGAF00002045187 cram 465.9 MB
EGAF00002045188 cram 251.1 MB
EGAF00002045189 cram 51.5 MB
EGAF00002045190 cram 24.7 MB
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EGAF00002045192 cram 134.9 MB
EGAF00002045193 cram 29.2 MB
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EGAF00002045195 cram 160.2 MB
EGAF00002045196 cram 35.3 MB
EGAF00002045197 cram 40.1 MB
EGAF00002045198 cram 29.7 MB
EGAF00002045199 cram 136.0 MB
EGAF00002045200 cram 139.1 MB
EGAF00002045201 cram 45.5 MB
EGAF00002045202 cram 44.0 MB
EGAF00002045203 cram 43.0 MB
EGAF00002045204 cram 40.7 MB
EGAF00002045205 cram 46.6 MB
EGAF00002045206 cram 32.7 MB
EGAF00002045207 cram 119.0 MB
EGAF00002045208 cram 118.7 MB
EGAF00002045209 cram 46.5 MB
EGAF00002045210 cram 42.2 MB
EGAF00002045211 cram 151.0 MB
EGAF00002045212 cram 43.5 MB
EGAF00002045213 cram 151.5 MB
EGAF00002045214 cram 124.3 MB
EGAF00002045215 cram 130.0 MB
EGAF00002045216 cram 1.0 MB
EGAF00002045217 cram 245.2 MB
EGAF00002045218 cram 241.2 MB
EGAF00002045219 cram 16.4 MB
EGAF00002045220 cram 34.9 MB
EGAF00002045221 cram 32.2 MB
EGAF00002045222 cram 126.8 MB
EGAF00002045223 cram 136.2 MB
EGAF00002045224 cram 31.7 MB
EGAF00002045225 cram 91.1 MB
EGAF00002045226 cram 10.6 MB
EGAF00002045227 cram 116.5 MB
EGAF00002045228 cram 23.6 MB
EGAF00002045229 cram 133.0 MB
EGAF00002045230 cram 198.0 MB
EGAF00002045231 cram 31.5 MB
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EGAF00002045234 cram 207.8 MB
EGAF00002045235 cram 28.0 MB
EGAF00002045236 cram 22.3 MB
EGAF00002045237 cram 9.0 MB
EGAF00002045238 cram 208.1 MB
EGAF00002045239 cram 127.4 MB
EGAF00002045240 cram 104.0 MB
EGAF00002045241 cram 218.6 MB
EGAF00002045242 cram 32.2 MB
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EGAF00002045244 cram 156.0 MB
EGAF00002045245 cram 412.0 MB
EGAF00002045246 cram 114.6 MB
EGAF00002045247 cram 137.9 MB
EGAF00002045248 cram 170.3 MB
EGAF00002045249 cram 159.7 MB
EGAF00002045250 cram 191.6 MB
EGAF00002045251 cram 182.1 MB
EGAF00002045252 cram 154.7 MB
EGAF00002045253 cram 104.5 MB
EGAF00002045254 cram 119.7 MB
EGAF00002045255 cram 136.7 MB
EGAF00002045256 cram 135.1 MB
EGAF00002045257 cram 141.8 MB
EGAF00002045258 cram 147.6 MB
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EGAF00002045260 cram 120.0 MB
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EGAF00002045262 cram 14.0 MB
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EGAF00002045268 cram 164.2 MB
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EGAF00002045285 cram 50.1 MB
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EGAF00002045287 cram 175.9 MB
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EGAF00002045337 cram 166.9 MB
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EGAF00002045356 cram 186.1 MB
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EGAF00002045360 cram 189.8 MB
EGAF00002045361 cram 44.2 MB
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EGAF00002045366 cram 44.3 MB
EGAF00002045367 cram 49.7 MB
EGAF00002045368 cram 187.0 MB
EGAF00002045369 cram 40.4 MB
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EGAF00002045371 cram 44.5 MB
EGAF00002045372 cram 23.6 MB
EGAF00002045373 cram 202.1 MB
EGAF00002045374 cram 177.7 MB
EGAF00002045375 cram 187.0 MB
EGAF00002045376 cram 169.6 MB
EGAF00002045377 cram 177.7 MB
EGAF00002045378 cram 169.9 MB
EGAF00002045379 cram 140.2 MB
EGAF00002045380 cram 165.3 MB
EGAF00002045381 cram 203.6 MB
EGAF00002045382 cram 255.2 MB
EGAF00002045383 cram 217.7 MB
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EGAF00002046472 cram 19.0 MB
EGAF00002046473 cram 145.4 MB
EGAF00002046474 cram 134.8 MB
EGAF00002046475 cram 125.7 MB
EGAF00002046476 cram 158.6 MB
EGAF00002046477 cram 161.9 MB
EGAF00002046478 cram 160.2 MB
EGAF00002046479 cram 150.8 MB
EGAF00002046480 cram 134.6 MB
EGAF00002046481 cram 348.3 MB
EGAF00002046482 cram 111.1 MB
EGAF00002046483 cram 158.1 MB
EGAF00002046484 cram 151.2 MB
EGAF00002046485 cram 146.2 MB
EGAF00002046486 cram 152.3 MB
EGAF00002046487 cram 386.3 MB
EGAF00002046488 cram 4.3 MB
EGAF00002046489 cram 202.2 MB
EGAF00002046490 cram 222.9 MB
EGAF00002046491 cram 20.4 MB
EGAF00002046492 cram 136.1 MB
EGAF00002046493 cram 122.2 MB
1632 Files (209.0 GB)