Mechanism and targeted therapy of Vemurafenib-Resistant Hairy-Cell Leukemia
The discovery of the BRAF V600E mutation in almost all cases of hairy-cell leukemia has led to the widespread adoption of the BRAF inhibitor vemurafenib for treatment of chemotherapy-resistant cases. Impressive responses are reported; however, acquired resistance is common. Whilst diverse mechanisms of vemurafenib resistance have been elucidated in melanoma, the basis of resistance in HCL is unclear. Here we apply whole genome and deep targeted sequencing to investigate resistance mechanisms and potential therapeutic strategies in a patient with aquired resistance to vemurafenib.
- 25/01/2018
- 15 samples
- DAC: EGAC00001000000
- Technology: Illumina HiSeq 2500
- PUB DUO:0000019 (version: 2021-02-23)publication requiredThis data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.
- US DUO:0000026 (version: 2021-02-23)user specific restrictionThis data use modifier indicates that use is limited to use by approved users.
- IS DUO:0000028 (version: 2021-02-23)institution specific restrictionThis data use modifier indicates that use is limited to use within an approved institution.
- GRU DUO:0000042 (version: 2021-02-23)general research useThis data use permission indicates that use is allowed for general research use for any research purpose.
Wellcome Trust Sanger Institute Cancer Genome Group Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001002261 | Cancer Genomics |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00001748881 | cram | 515.6 MB | ||
| EGAF00001748882 | cram | 475.3 MB | ||
| EGAF00001748883 | cram | 508.0 MB | ||
| EGAF00001748884 | cram | 532.7 MB | ||
| EGAF00001748885 | cram | 488.4 MB | ||
| EGAF00001748886 | cram | 512.7 MB | ||
| EGAF00001748887 | cram | 489.9 MB | ||
| EGAF00001748888 | cram | 607.9 MB | ||
| EGAF00001748889 | cram | 620.3 MB | ||
| EGAF00001748890 | cram | 625.2 MB | ||
| EGAF00001748891 | cram | 665.5 MB | ||
| EGAF00001748892 | cram | 593.7 MB | ||
| EGAF00001748893 | cram | 590.3 MB | ||
| EGAF00001748894 | cram | 598.7 MB | ||
| EGAF00001748895 | cram | 554.4 MB | ||
| EGAF00001748896 | cram | 513.8 MB | ||
| EGAF00001748897 | cram | 473.7 MB | ||
| EGAF00001748898 | cram | 506.3 MB | ||
| EGAF00001748899 | cram | 530.7 MB | ||
| EGAF00001748900 | cram | 486.5 MB | ||
| EGAF00001748901 | cram | 511.0 MB | ||
| EGAF00001748902 | cram | 488.3 MB | ||
| EGAF00001748903 | cram | 605.7 MB | ||
| EGAF00001748904 | cram | 618.6 MB | ||
| EGAF00001748905 | cram | 623.0 MB | ||
| EGAF00001748906 | cram | 662.7 MB | ||
| EGAF00001748907 | cram | 591.2 MB | ||
| EGAF00001748908 | cram | 587.8 MB | ||
| EGAF00001748909 | cram | 596.2 MB | ||
| EGAF00001748910 | cram | 552.5 MB | ||
| EGAF00001748911 | cram | 512.7 MB | ||
| EGAF00001748912 | cram | 473.2 MB | ||
| EGAF00001748913 | cram | 505.4 MB | ||
| EGAF00001748914 | cram | 530.2 MB | ||
| EGAF00001748915 | cram | 486.0 MB | ||
| EGAF00001748916 | cram | 510.1 MB | ||
| EGAF00001748917 | cram | 487.5 MB | ||
| EGAF00001748918 | cram | 604.6 MB | ||
| EGAF00001748919 | cram | 617.7 MB | ||
| EGAF00001748920 | cram | 622.3 MB | ||
| EGAF00001748921 | cram | 661.9 MB | ||
| EGAF00001748922 | cram | 590.3 MB | ||
| EGAF00001748923 | cram | 587.1 MB | ||
| EGAF00001748924 | cram | 595.2 MB | ||
| EGAF00001748925 | cram | 551.6 MB | ||
| EGAF00001748926 | cram | 512.0 MB | ||
| EGAF00001748927 | cram | 472.6 MB | ||
| EGAF00001748928 | cram | 504.9 MB | ||
| EGAF00001748929 | cram | 529.2 MB | ||
| EGAF00001748930 | cram | 485.4 MB | ||
| EGAF00001748931 | cram | 509.6 MB | ||
| EGAF00001748932 | cram | 486.6 MB | ||
| EGAF00001748933 | cram | 604.3 MB | ||
| EGAF00001748934 | cram | 617.1 MB | ||
| EGAF00001748935 | cram | 621.6 MB | ||
| EGAF00001748936 | cram | 661.0 MB | ||
| EGAF00001748937 | cram | 590.0 MB | ||
| EGAF00001748938 | cram | 586.7 MB | ||
| EGAF00001748939 | cram | 595.0 MB | ||
| EGAF00001748940 | cram | 551.3 MB | ||
| EGAF00001748941 | cram | 511.4 MB | ||
| EGAF00001748942 | cram | 471.5 MB | ||
| EGAF00001748943 | cram | 503.8 MB | ||
| EGAF00001748944 | cram | 528.3 MB | ||
| EGAF00001748945 | cram | 484.2 MB | ||
| EGAF00001748946 | cram | 508.7 MB | ||
| EGAF00001748947 | cram | 485.8 MB | ||
| EGAF00001748948 | cram | 602.9 MB | ||
| EGAF00001748949 | cram | 615.6 MB | ||
| EGAF00001748950 | cram | 620.0 MB | ||
| EGAF00001748951 | cram | 659.4 MB | ||
| EGAF00001748952 | cram | 588.6 MB | ||
| EGAF00001748953 | cram | 585.1 MB | ||
| EGAF00001748954 | cram | 593.3 MB | ||
| EGAF00001748955 | cram | 549.6 MB | ||
| 75 Files (41.7 GB) | ||||