Exome sequencing and RNAseq data

Material Transfer Agreement and Data Request Form

Material Transfer Agreement This Material Transfer Agreement (the “Agreement”) is made effective as of the YYYY/MM/DD (the “Effective Date”) by and between The Department of Oncology of the University of Turin, located at the Candiolo Cancer Institute with an address at SP 142 Km 3,95 – Candiolo (TO) 10060 - Italy (“UNIVERSITY”); and (“INSTITUTION”) Recitals WHEREAS, UNIVERSITY owns or otherwise controls the Materials (as defined below); and WHEREAS, Dr. __________(RECIPIENT) desires to obtain samples of the Materials and use such samples for the purpose of conducting the Research (as defined below); and WHEREAS, UNIVERSITY is willing to furnish the Materials to RECIPIENT, upon the terms and conditions set forth herein. I. The material ("Material") created by Alberto Bardelli, that is covered by this Agreement include: a. Bioinformatic pipelines, algorithms and raw data of Next Generation Sequencing b. Any related biological material or associated know how and data that will be received by RECIPIENT from UNIVERSITY; and c. Any substantially similar material or progeny of the Material (including associated know-how and data) that is replicated or derived there from RECIPIENT or his co-workers and that could not have been made but from the Material, know how, or data supplied by UNIVERSITY: II. The Material will be used solely for the research purposes described in paragraph III. It may not be used for any commercial purpose or to generate data, intellectual property or knowhow that will be used to support the development of any commercial product. III. The following is a brief statement of the permitted use of the Material (please include purpose and duration of the study) The above-mentioned Material will not be used for commercial purposes and any publication will include authors from Bardelli’s laboratory as appropriate pursuant to standard academic custom. Please provide a brief summary about the purpose and duration of the study. ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ Promptly following completion of the research purpose described in Paragraph III. or upon termination of this Agreement, RECIPIENT or INSTITUTION will send a confidential summary of results acquired through use of the Material to UNIVERSITY. IV. The Material listed above is considered proprietary to UNIVERSITY, and will be returned to UNIVERSITY upon request in the event of termination. RECIPIENT and INSTITUTION shall not distribute or release the Material to any person other than laboratory personnel under RECIPIENT’s direct supervision and shall ensure that no one will be allowed to take or send this Material to any other location unless written permission is obtained from UNIVERSITY. UNIVERSITY will control future distributions of the material. At the written request of UNIVERSITY, RECIPIENT will cease to use or destroy Material. Unused Material not destroyed (at UNIVERSITY's option) will be returned to UNIVERSITY. V. The Material transferred pursuant to this Agreement (a) shall be used by RECIPIENT only for the research purpose and shall at all times remain solely under the control of RECIPIENT; (b) shall not be used by RECIPIENT in research or testing involving human subjects. VI. RECIPIENT and INSTITUTION agree that nothing herein shall be deemed to grant neither any right under any UNIVERSITY patents nor any rights to use the Material nor any products or processes involving the Material for profit-making or commercial purposes. The Material will not be used in research that is subject to consulting or licensing obligations to another corporation, institution, or business entity unless written permission is obtained from UNIVERSITY. VII. THE MATERIAL IS EXPERIMENTAL IN NATURE AND IS PROVIDED WITHOUT WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED. UNIVERSITY MAKES NO REPRESENTATION OR WARRANTY THAT THE MANUFACTURE, SALE, TRANSFER OR USE OF THE MATERIAL WILL NOT INFRINGE ANY PATENT OR PROPRIETARY RIGHT OF OTHERS. VIII RECIPIENT shall have the exclusive right to publish or otherwise disclose the Results. Acknowledgement of the source of Material will be done in accordance with normal academic custom, including a maximum of two UNIVERSITY scientists among the Authors as appropriate. RECIPIENT and/or INSTITUTION will provide UNIVERSITY with preprints of abstracts, presentations and manuscript or summaries regarding the use the Material at least 30 days prior to submission for publication or presentation for informational purposes. RECIPIENT and INSTITUTION will promptly notify UNIVERSITY of and will grant UNIVERSITY a worldwide, royalty free, non-exclusive, sublicensable license to practice any invention relating to the Material, whether or not patentable. IX. In no event shall UNIVERSITY be liable for any use by RECIPIENT of the Material or any loss, claim, damage or liability, of whatsoever kind or nature, which may arise from or in connection with this Agreement or the use, handling or storage of the Material by RECIPIENT. X. RECIPIENT agrees to comply with all applicable laws, rules and regulations relating to the care, welfare, handling, breeding, storage, transfer and disposal of the Material, including all laws relating to shipment to and from (and which will be made F.O.B.) UNIVERSITY, Candiolo, Italy. RECIPIENT agrees to waive all claims against UNIVERSITY and to indemnify, defend and hold harmless UNIVERSITY, its employees and agents from and against all claims, damages and liability that may be asserted by third parties arising out of the use, care, handling, disposal, transfer, breeding and shipment of the Material. XI. Should any provision of this agreement be invalid or unenforceable the remaining provisions shall be valid. In the place of an invalid provision, a valid provision is presumed to be agreed upon by the parties, which comes economically closest to the invalid provision. This agreement shall be construed according to the material laws of Italy. The parties agree that for all disputes or claims arising under this Agreement the Foro of Torino, Italy shall have jurisdiction. This wording contains the entire agreement between the parties; any changes of the agreement have to be made in writing. RECIPIENT is an employee of INSTITUTION and this Agreement is by and between UNIVERSITY and INSTITUTION as the parties, with RECIPIENT acknowledging its terms. Date: Date: For UNIVERSITY: For INSTITUTION: .................................................. ................................................... Prof. Federico Bussolino Name: Full Professor and Dept. Deputy Director READ AND UNDERSTOOD: ……………………………………. RECIPIENT Dear RECIPIENT: Please indicate your agreement to the terms of the TRANSFER OF BIOLOGICAL MATERIAL above by your signature and countersignature by an official representative of your Institution and return this letter to us. Upon receipt, UNIVERSITY will send you the Material. Thank you for your assistance. Data Request Form Applications for access to data can be submitted by emailing this completely filled document to alberto.bardelli@ircc.it. The Data Access Committee of the Department of Oncology, University of Turin will consider applications and respond within 8 weeks. Principal Investigator must complete the following form in all its part, including full institution contact details, a signature and stamp of an institute official. Personal email addresses (e.g. Hotmail, Gmail etc.) are not accepted. Incomplete application forms will not be taken into consideration and send back to the applicant. Principal Investigator: Full name: Title: Organization/Center: Department: Full address: Email: Phone number: Requested data (describe type and format of requested data specifying archive accession codes if available): Please state any (at least one) peer-reviewed publications of the applicant that are related to the intended research project: Is the project part of a consortium/current collaboration? If yes, please state the centers/institutes and researchers involved: Please state all involved researchers and affiliations, including consortium members and collaborators that will have access to the data or are involved in the research: Project Proposal: Project title: Short project summary: Research question: Please describe how the requested data specifically contributes to addressing your research question: Importance of the project in the research field (please include your reasoning and/or scientific articles supporting it): Please state the methods that you are applying during your project (how will you structure your project? What statistic measures will you use? Are any patients involved in? If yes, how many patients will be included?): Do you have any questions and/or remarks? I hereby declare that the information provided in this ‘Data Request Form’ is true and correct. I understand that this ‘Data Request Form’, including revisions and/or restrictions imposed by the Data Access Committee, is part of the final, legal agreement. Signature of the Principle Investigator, including name, date and institutional stamp. ________________ ____________________ Date Signature