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Epigenome maps of time-resolved monocyte to macrophage differentiation and innate immune memory

Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as LPS. We apply an integrated epigenomic approach to characterize the molecular events involved in LPS-induced tolerance in a time dependent manner. ChIP-seq, RNA-seq, WGBS and ATAC-seq data were generated. This analysis identified epigenetic programs in tolerance and trained macrophages, and the potential transcription factors involved. Experimental set-up Time-course in vitro culture of human monocytes. Two innate immune memory states can be induced in culture through an initial exposure of primary human monocytes to either LPS or BG for 24 hours, followed by removal of stimulus and differentiation to macrophages for an additional 5 days. Cells were collected at baseline (day 0), 1 hour, 4 hour, 24 hour and 6 days.

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Access to the sequence and alignment and genotype level data produced by the Blueprint Consortium is controlled by the Blueprint Data Access Committee (DAC). Access to data will be granted to qualified investigators for appropriate use. Please email blueprint-dac@ebi.ac.uk to request data access.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Epigenetics
Epigenetics
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000949275 bam 6.0 GB
EGAF00000949276 bam 7.0 GB
EGAF00000949277 bam 5.9 GB
EGAF00000949278 bam 8.4 GB
EGAF00000949279 bam 6.6 GB
EGAF00000949280 bam 7.8 GB
EGAF00000949281 bam 6.4 GB
EGAF00000949282 bam 9.2 GB
EGAF00000949283 bam 5.9 GB
EGAF00000949284 bam 7.0 GB
EGAF00000949285 bam 5.8 GB
EGAF00000949286 bam 8.3 GB
EGAF00000949287 bam 7.5 GB
EGAF00000949288 bam 8.2 GB
EGAF00000949289 bam 7.5 GB
EGAF00000949290 bam 8.0 GB
EGAF00000949291 bam 7.4 GB
EGAF00000949292 bam 8.1 GB
EGAF00000949293 bam 7.5 GB
EGAF00000949294 bam 8.1 GB
EGAF00000949295 bam 7.6 GB
EGAF00000949296 bam 7.1 GB
EGAF00000949298 bam 6.5 GB
EGAF00000949299 bam 7.9 GB
EGAF00000949300 bam 7.5 GB
EGAF00000949301 bam 7.7 GB
EGAF00000949302 bam 6.5 GB
EGAF00000949303 bam 8.2 GB
EGAF00000949304 bam 7.1 GB
EGAF00000949305 bam 7.8 GB
EGAF00000949306 bam 7.2 GB
EGAF00000949307 bam 7.8 GB
EGAF00000949308 bam 6.5 GB
EGAF00000949309 bam 7.1 GB
EGAF00000949310 bam 6.5 GB
EGAF00000949311 bam 7.1 GB
EGAF00000949312 bam 6.8 GB
EGAF00000949313 bam 7.4 GB
EGAF00000949314 bam 6.8 GB
EGAF00000949315 bam 7.4 GB
EGAF00000949316 bam 7.0 GB
EGAF00000949317 bam 7.7 GB
EGAF00000949318 bam 7.1 GB
EGAF00000949319 bam 7.6 GB
EGAF00000949320 bam 7.8 GB
EGAF00000949321 bam 7.3 GB
EGAF00000949323 bam 6.5 GB
EGAF00000949324 bam 7.2 GB
EGAF00000949325 bam 6.6 GB
EGAF00000949327 bam 6.0 GB
EGAF00000949328 bam 7.5 GB
EGAF00000949329 bam 7.0 GB
EGAF00000949331 bam 6.2 GB
EGAF00000949332 bam 8.4 GB
EGAF00000949333 bam 7.7 GB
EGAF00000949334 bam 8.2 GB
EGAF00000949335 bam 6.6 GB
EGAF00000949336 bam 8.4 GB
EGAF00000949337 bam 7.8 GB
EGAF00000949338 bam 8.3 GB
EGAF00000949339 bam 6.7 GB
EGAF00000949340 bam 8.4 GB
EGAF00000949341 bam 7.7 GB
EGAF00000949342 bam 8.2 GB
EGAF00000949343 bam 6.6 GB
EGAF00000949344 bam 7.9 GB
EGAF00000949345 bam 7.3 GB
EGAF00000949346 bam 7.8 GB
EGAF00000949347 bam 6.3 GB
EGAF00000949348 bam 8.8 GB
EGAF00000949349 bam 8.9 GB
EGAF00000949350 bam 8.7 GB
EGAF00000949351 bam 7.9 GB
EGAF00000949352 bam 7.4 GB
EGAF00000949353 bam 7.7 GB
EGAF00000949354 bam 6.4 GB
EGAF00000949355 bam 8.2 GB
EGAF00000949356 bam 7.7 GB
EGAF00000949357 bam 8.0 GB
EGAF00000949358 bam 6.6 GB
EGAF00000949359 bam 7.9 GB
EGAF00000949360 bam 7.4 GB
EGAF00000949361 bam 7.7 GB
EGAF00000949362 bam 6.4 GB
EGAF00000949363 bam 7.8 GB
EGAF00000949364 bam 7.3 GB
EGAF00000949365 bam 7.6 GB
EGAF00000949366 bam 6.3 GB
EGAF00000949367 bam 8.2 GB
EGAF00000949368 bam 7.7 GB
EGAF00000949369 bam 6.6 GB
EGAF00000949370 bam 7.3 GB
EGAF00000949371 bam 6.7 GB
EGAF00000949372 bam 7.3 GB
EGAF00000949373 bam 6.5 GB
EGAF00000949374 bam 7.2 GB
EGAF00000949375 bam 6.6 GB
EGAF00000949376 bam 7.2 GB
EGAF00000949377 bam 6.1 GB
EGAF00000949378 bam 6.9 GB
EGAF00000949379 bam 6.3 GB
EGAF00000949380 bam 6.7 GB
EGAF00000949381 bam 7.3 GB
EGAF00000949382 bam 6.9 GB
EGAF00000949384 bam 6.1 GB
EGAF00000949385 bam 7.3 GB
EGAF00000949386 bam 6.8 GB
EGAF00000949388 bam 6.0 GB
EGAF00000949389 bam 6.9 GB
EGAF00000949390 bam 6.6 GB
EGAF00000949392 bam 5.8 GB
EGAF00000949393 bam 7.0 GB
EGAF00000949394 bam 6.7 GB
EGAF00000949396 bam 5.9 GB
EGAF00000949397 bam 5.5 GB
EGAF00000949398 bam 5.2 GB
EGAF00000949400 bam 4.6 GB
EGAF00000949401 bam 8.1 GB
EGAF00000949402 bam 7.1 GB
EGAF00000949403 bam 8.6 GB
EGAF00000949404 bam 6.9 GB
EGAF00000949405 bam 8.1 GB
EGAF00000949406 bam 7.1 GB
EGAF00000949407 bam 8.6 GB
EGAF00000949408 bam 6.9 GB
EGAF00000949409 bam 8.3 GB
EGAF00000949410 bam 7.2 GB
EGAF00000949411 bam 8.7 GB
EGAF00000949412 bam 7.0 GB
EGAF00000949413 bam 7.4 GB
EGAF00000949414 bam 7.6 GB
EGAF00000949416 bam 8.7 GB
EGAF00000949417 bam 7.3 GB
EGAF00000949418 bam 7.4 GB
EGAF00000949420 bam 8.6 GB
EGAF00000949421 bam 8.3 GB
EGAF00000949422 bam 7.2 GB
EGAF00000949423 bam 8.7 GB
EGAF00000949424 bam 7.0 GB
EGAF00000949425 bam 7.2 GB
EGAF00000949426 bam 7.3 GB
EGAF00000949428 bam 8.3 GB
EGAF00000949429 bam 6.9 GB
EGAF00000949430 bam 7.9 GB
EGAF00000949431 bam 7.2 GB
EGAF00000949432 bam 9.5 GB
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EGAF00000949434 bam 10.1 GB
EGAF00000949435 bam 10.0 GB
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EGAF00000949438 bam 6.0 GB
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EGAF00000949440 bam 4.5 GB
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EGAF00000949450 bam 6.8 GB
EGAF00000949451 bam 7.0 GB
EGAF00000949453 bam 8.4 GB
EGAF00000949454 bam 2.0 GB
EGAF00000949455 bam 3.6 GB
EGAF00000949456 bam 5.5 GB
EGAF00000949457 bam 23.6 GB
EGAF00000949458 bam 28.7 GB
EGAF00000949459 bam 27.5 GB
EGAF00000949460 bam 12.8 GB
EGAF00001051218 fastq.gz 1.4 GB
EGAF00001051219 fastq.gz 1.4 GB
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EGAF00001051221 fastq.gz 2.0 GB
EGAF00001051222 fastq.gz 1.3 GB
EGAF00001051223 fastq.gz 1.4 GB
EGAF00001051224 fastq.gz 1.2 GB
EGAF00001051225 fastq.gz 1.3 GB
EGAF00001051226 fastq.gz 1.2 GB
EGAF00001051227 fastq.gz 1.3 GB
EGAF00001051228 fastq.gz 1.3 GB
EGAF00001051229 fastq.gz 1.4 GB
EGAF00001051230 fastq.gz 1.4 GB
EGAF00001051231 fastq.gz 1.4 GB
EGAF00001051264 fastq.gz 1.3 GB
EGAF00001051265 fastq.gz 1.4 GB
EGAF00001051266 fastq.gz 1.4 GB
EGAF00001051267 fastq.gz 1.4 GB
EGAF00001051268 fastq.gz 1.2 GB
EGAF00001051269 fastq.gz 1.2 GB
EGAF00001051270 fastq.gz 1.1 GB
EGAF00001051271 fastq.gz 1.1 GB
EGAF00001051272 fastq.gz 1.1 GB
EGAF00001051273 fastq.gz 1.2 GB
EGAF00001063129 fastq.gz 955.4 MB
EGAF00001063130 fastq.gz 757.7 MB
EGAF00001065239 fastq.gz 492.2 MB
EGAF00001065240 fastq.gz 933.6 MB
EGAF00001065266 fastq.gz 898.9 MB
EGAF00001159095 fastq.gz 1.1 GB
EGAF00001159124 fastq.gz 1.2 GB
EGAF00001159125 fastq.gz 1.2 GB
EGAF00001159126 fastq.gz 1.3 GB
EGAF00001159127 fastq.gz 1.0 GB
EGAF00001159128 fastq.gz 1.2 GB
EGAF00001159199 fastq.gz 1.3 GB
EGAF00001159200 fastq.gz 1.4 GB
EGAF00001159236 fastq.gz 2.1 GB
EGAF00001159245 fastq.gz 1.9 GB
EGAF00001159246 fastq.gz 1.8 GB
EGAF00001159247 fastq.gz 1.8 GB
EGAF00001159248 fastq.gz 1.4 GB
EGAF00001159249 fastq.gz 1.6 GB
EGAF00001159250 fastq.gz 1.4 GB
EGAF00001159251 fastq.gz 1.2 GB
EGAF00001159252 fastq.gz 2.0 GB
EGAF00001159253 fastq.gz 1.9 GB
EGAF00001159254 fastq.gz 2.0 GB
EGAF00001159255 fastq.gz 1.7 GB
EGAF00001159256 fastq.gz 1.4 GB
EGAF00001159257 fastq.gz 1.5 GB
EGAF00001159258 fastq.gz 2.0 GB
EGAF00001159269 fastq.gz 1.8 GB
EGAF00001159270 fastq.gz 1.8 GB
EGAF00001159271 fastq.gz 1.6 GB
EGAF00001159272 fastq.gz 1.5 GB
EGAF00001159273 fastq.gz 1.6 GB
EGAF00001159289 fastq.gz 1.7 GB
EGAF00001159290 fastq.gz 1.8 GB
EGAF00001159291 fastq.gz 1.5 GB
EGAF00001159292 fastq.gz 1.9 GB
EGAF00001159293 fastq.gz 1.8 GB
EGAF00001173559 fastq.gz 1.7 GB
EGAF00001173560 fastq.gz 2.0 GB
EGAF00001173561 fastq.gz 1.8 GB
EGAF00001173562 fastq.gz 1.5 GB
EGAF00001173563 fastq.gz 1.6 GB
EGAF00001173564 fastq.gz 1.1 GB
EGAF00001173565 fastq.gz 1.5 GB
EGAF00001173566 fastq.gz 1.2 GB
EGAF00001173567 fastq.gz 1.6 GB
EGAF00001173568 fastq.gz 1.7 GB
EGAF00001173569 fastq.gz 1.5 GB
EGAF00001173570 fastq.gz 1.3 GB
EGAF00001173571 fastq.gz 1.7 GB
EGAF00001173572 fastq.gz 1.1 GB
EGAF00001173573 fastq.gz 1.5 GB
EGAF00001173574 fastq.gz 2.1 GB
EGAF00001173575 fastq.gz 1.2 GB
EGAF00001173576 fastq.gz 1.3 GB
EGAF00001173577 fastq.gz 1.9 GB
EGAF00001173578 fastq.gz 1.5 GB
EGAF00001173586 fastq.gz 863.3 MB
EGAF00001173587 fastq.gz 1.1 GB
EGAF00001173588 fastq.gz 1.5 GB
EGAF00001173589 fastq.gz 1.8 GB
EGAF00001173590 fastq.gz 1.7 GB
EGAF00001173591 fastq.gz 1.7 GB
EGAF00001173592 fastq.gz 1.8 GB
EGAF00001173593 fastq.gz 2.1 GB
EGAF00001173594 fastq.gz 2.0 GB
EGAF00001173595 fastq.gz 1.9 GB
EGAF00001173596 fastq.gz 2.3 GB
EGAF00001173597 fastq.gz 2.2 GB
EGAF00001173598 fastq.gz 1.2 GB
EGAF00001173599 fastq.gz 1.2 GB
EGAF00001173600 fastq.gz 578.1 MB
EGAF00001173601 fastq.gz 601.4 MB
EGAF00001173602 fastq.gz 524.5 MB
EGAF00001173621 fastq.gz 1.6 GB
EGAF00001173622 fastq.gz 1.4 GB
EGAF00001173623 fastq.gz 1.6 GB
EGAF00001173624 fastq.gz 1.4 GB
EGAF00001173625 fastq.gz 1.4 GB
EGAF00001173626 fastq.gz 1.5 GB
EGAF00001173644 fastq.gz 743.9 MB
EGAF00001173645 fastq.gz 625.7 MB
EGAF00001173646 fastq.gz 1.8 GB
EGAF00001173647 fastq.gz 500.7 MB
EGAF00001173648 fastq.gz 419.5 MB
EGAF00001173653 fastq.gz 1.3 GB
EGAF00001173654 fastq.gz 1.7 GB
EGAF00001173655 fastq.gz 1.3 GB
EGAF00001173656 fastq.gz 1.6 GB
EGAF00001173657 fastq.gz 1.6 GB
EGAF00001173658 fastq.gz 1.4 GB
EGAF00001173659 fastq.gz 1.4 GB
EGAF00001173660 fastq.gz 1.5 GB
EGAF00001173661 fastq.gz 1.7 GB
EGAF00001173662 fastq.gz 1.8 GB
EGAF00001173663 fastq.gz 1.5 GB
EGAF00001173664 fastq.gz 1.7 GB
EGAF00001173665 fastq.gz 1.6 GB
EGAF00001173666 fastq.gz 1.6 GB
EGAF00001173667 fastq.gz 1.7 GB
EGAF00001173668 fastq.gz 1.9 GB
EGAF00001173672 fastq.gz 2.2 GB
EGAF00001173673 fastq.gz 2.2 GB
EGAF00001173674 fastq.gz 2.0 GB
EGAF00001173677 fastq.gz 1.6 GB
EGAF00001173678 fastq.gz 409.5 MB
EGAF00001173679 fastq.gz 1.5 GB
EGAF00001173680 fastq.gz 1.4 GB
EGAF00001173681 fastq.gz 1.4 GB
EGAF00001173682 fastq.gz 1.6 GB
EGAF00001173683 fastq.gz 1.4 GB
EGAF00001173684 fastq.gz 1.3 GB
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EGAF00001173686 fastq.gz 1.2 GB
EGAF00001236233 bam 1.1 GB
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EGAF00001236252 bam 604.2 MB
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EGAF00001236278 bam 1.6 GB
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EGAF00001236338 bam 1.5 GB
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EGAF00001236399 bam 1.8 GB
EGAF00001236405 bam 1.9 GB
EGAF00001236412 bam 328.2 MB
EGAF00001236415 bam 1.5 GB
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EGAF00001236434 bam 1.3 GB
EGAF00001236464 bam 923.7 MB
EGAF00001236469 bam 1.5 GB
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EGAF00001335865 bam 2.6 GB
450 Files (3.2 TB)