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Expression quantitative trait locus mapping in human pancreatic islets of Langerhans

The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act remain poorly characterized. To identify such effector transcripts for T2D and glycemic traits, we generated expression quantitative trait locus (eQTL) data in 118 human islet samples using RNA-sequencing and high-density genotyping.

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Oxford Human Islet Genotypes & RNA-seq Data Access Agreement

This agreement governs the terms on which access will be granted to the RNA-sequencing and genotype data generated as part of the “cis-eQTL mapping of human pancreatic islets” study.In signing this agreement, You are agreeing to be bound by the terms and conditions of access set out in this agreement.For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User’s Institution (as defined below). User Institution and User are referred to within the agreement as “You” and “Your” shall be construed accordingly.Definitions:Investigators means the group of investigators based in Oxford, UK, and Edmonton, Canada, which have generated the Data.Data means all and any human genetic data obtained from the Investigators.Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto.User means a researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance.Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research.User Institution means the organisation at which the User is employed, affiliated or enrolled.Terms and Conditions: In signing this Agreement:1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors.2. You agree not to use the Data or any part thereof for the creation of products for sale or for any commercial purpose.3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy.4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevant access committees.5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outside the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval.7. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives.8. You accept that the Investigators, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied:a. bear no legal responsibility for the accuracy or comprehensiveness of the Data; andb. accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason.9. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted.10. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data.11. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held.12. You accept that it may be necessary for the Investigators or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Investigators or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement.13. You accept that the Data is protected by and subject to international laws, including but not limited to the UK Data Protection Act 1998, and that You are responsible for ensuring compliance with any such applicable law. The Oxford Human Islet Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA.14. This agreement shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the non-exclusive jurisdiction of the English courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Metagenomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000826493 bam 11.4 GB
EGAF00000826494 bam 11.3 GB
EGAF00000826495 bam 8.0 GB
EGAF00000826496 bam 12.5 GB
EGAF00000826497 bam 6.9 GB
EGAF00000826498 bam 13.1 GB
EGAF00000826499 bam 9.0 GB
EGAF00000826500 bam 15.8 GB
EGAF00000826501 bam 9.3 GB
EGAF00000826502 bam 10.6 GB
EGAF00000826503 bam 9.5 GB
EGAF00000826504 bam 11.6 GB
EGAF00000826505 bam 11.9 GB
EGAF00000826506 bam 14.3 GB
EGAF00000826507 bam 9.4 GB
EGAF00000826508 bam 11.2 GB
EGAF00000826509 bam 9.4 GB
EGAF00000826510 bam 8.1 GB
EGAF00000826511 bam 8.1 GB
EGAF00000826512 bam 8.2 GB
EGAF00000826513 bam 8.4 GB
EGAF00000826514 bam 7.6 GB
EGAF00000826515 bam 8.0 GB
EGAF00000826516 bam 8.6 GB
EGAF00000826517 bam 8.3 GB
EGAF00000826518 bam 9.1 GB
EGAF00000826519 bam 8.2 GB
EGAF00000826520 bam 7.3 GB
EGAF00000826521 bam 8.5 GB
EGAF00000826522 bam 9.7 GB
EGAF00000826523 bam 10.9 GB
EGAF00000826524 bam 11.4 GB
EGAF00000826525 bam 10.1 GB
EGAF00000826526 bam 9.3 GB
EGAF00000826527 bam 9.1 GB
EGAF00000826528 bam 9.9 GB
EGAF00000826529 bam 10.5 GB
EGAF00000826530 bam 10.1 GB
EGAF00000826531 bam 10.0 GB
EGAF00000826532 bam 11.6 GB
EGAF00000826533 bam 12.2 GB
EGAF00000826534 bam 10.5 GB
EGAF00000826535 bam 8.3 GB
EGAF00000826541 bam 10.2 GB
EGAF00000826542 bam 10.3 GB
EGAF00000826543 bam 11.1 GB
EGAF00000826544 bam 10.5 GB
EGAF00000826545 bam 8.3 GB
EGAF00000826546 bam 4.5 GB
EGAF00000826547 bam 18.5 GB
EGAF00000826548 bam 11.1 GB
EGAF00000826549 bam 19.1 GB
EGAF00000826550 bam 15.5 GB
EGAF00000826551 bam 10.9 GB
EGAF00000826552 bam 10.2 GB
EGAF00000826553 bam 10.9 GB
EGAF00000826554 bam 9.4 GB
EGAF00000826555 bam 10.7 GB
EGAF00000826556 bam 11.6 GB
EGAF00000826557 bam 12.1 GB
EGAF00000826558 bam 11.6 GB
EGAF00000826559 bam 10.7 GB
EGAF00000826560 bam 12.4 GB
EGAF00000826561 bam 10.5 GB
EGAF00000826562 bam 7.9 GB
EGAF00000826563 bam 12.7 GB
EGAF00000826564 bam 9.1 GB
EGAF00000826565 bam 7.2 GB
EGAF00000826566 bam 10.4 GB
EGAF00000826567 bam 10.1 GB
EGAF00000826568 bam 11.0 GB
EGAF00000826569 bam 11.9 GB
EGAF00000826570 bam 10.6 GB
EGAF00000826571 bam 10.6 GB
EGAF00000826572 bam 9.8 GB
EGAF00000826573 bam 13.9 GB
EGAF00000826574 bam 10.6 GB
EGAF00000826575 bam 8.7 GB
EGAF00000826576 bam 12.0 GB
EGAF00000826577 bam 8.9 GB
EGAF00000826578 bam 8.2 GB
EGAF00000826579 bam 8.5 GB
EGAF00000826580 bam 10.8 GB
EGAF00000826581 bam 9.0 GB
EGAF00000826582 bam 8.1 GB
EGAF00000826583 bam 11.2 GB
EGAF00000826584 bam 7.5 GB
EGAF00000826585 bam 11.0 GB
EGAF00000826586 bam 10.6 GB
EGAF00000826587 bam 11.8 GB
EGAF00000826588 bam 10.7 GB
EGAF00000826589 bam 9.7 GB
EGAF00000826590 bam 10.6 GB
EGAF00000826591 bam 12.5 GB
EGAF00000826592 bam 11.3 GB
EGAF00000826593 bam 11.4 GB
EGAF00000826594 bam 8.0 GB
EGAF00000826610 bam 4.4 GB
EGAF00000826611 bam 9.6 GB
EGAF00000826612 bam 9.9 GB
EGAF00000826613 bam 11.4 GB
EGAF00000826614 bam 10.2 GB
EGAF00000826615 bam 11.4 GB
EGAF00000826616 bam 10.9 GB
EGAF00000826617 bam 10.3 GB
EGAF00000826618 bam 10.6 GB
EGAF00000826619 bam 11.8 GB
EGAF00000826620 bam 9.5 GB
EGAF00000826621 bam 9.2 GB
EGAF00000826622 bam 11.6 GB
EGAF00000826623 bam 10.8 GB
EGAF00000826624 bam 9.6 GB
EGAF00000826625 bam 9.8 GB
EGAF00000826626 bam 14.0 GB
EGAF00000826627 bam 10.7 GB
EGAF00000826628 bam 11.1 GB
EGAF00000826629 bam 9.0 GB
EGAF00000826630 bam 8.0 GB
EGAF00002207838 vcf.gz 1.4 GB
119 Files (1.2 TB)