Chronic lymphocytic leukemia driven by paradoxical ERK activation during BRAF inhibitor treatment
Whole-exome sequencing of a chronic lymphocytic leukemia (CLL) developed during vemurafenib treatment of a patient with malignant melanoma. Peripheral blood mononuclear cells were separated by Ficoll gradient centrifugation. DNA was extracted from highly purified (>97%) CD19+CD5+ cells obtained from the patient while being under BRAF inhibition versus CD14+ germline control cells (>90% purity). No alterations that could be linked to aberrant RAS activity or paradoxical RAF/MEK/ERK signaling could be identified in the CLL, which shows characteristic copy number alterations.
- 29/03/2016
- 2 samples
- DAC: EGAC00001000452
- Technology: Illumina HiSeq 2500
Data Transfer Agreement for the German Cancer Research Center
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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00000603178 | fastq.gz | 4.6 GB | ||
| EGAF00000603179 | fastq.gz | 4.9 GB | ||
| EGAF00000603180 | fastq.gz | 4.0 GB | ||
| EGAF00000603181 | fastq.gz | 4.3 GB | ||
| 4 Files (17.9 GB) | ||||