Combination therapies for personalized cancer medicine
It is the ambition of the team formed by members of the Netherlands Cancer Institute (NKI) and the Cancer Genome Project at the Wellcome Trust Sanger Institute (WTSI) to unravel the genomic and phenotypic complexity of human cancers in order to identify optimal drug combinations for personalized cancer therapy. Our integrated approach will entail (i) deep sequencing of human tumours and cognate mouse tumours; (ii) drug screens in a 1000+ fully characterized tumour cell line panel; (iii) high-throughput in vitro and in vivo shRNA and cDNA drug resistance and enhancement screens; (iv) computational analysis of the acquired data, leading to significant response predictions; (v) rigorous validation of these predictions in genetically engineered mouse models and patient-derived xenografts. This integrated effort is expected to yield a number of combination therapies and companion-diagnostics biomarkers that will be further explored in our existing clinical trial networks.
- 24/08/2016
- 62 samples
- DAC: EGAC00001000000
- Technology: Illumina HiSeq 2000
- PUB DUO:0000019 (version: 2021-02-23)publication requiredThis data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.
- US DUO:0000026 (version: 2021-02-23)user specific restrictionThis data use modifier indicates that use is limited to use by approved users.
- IS DUO:0000028 (version: 2021-02-23)institution specific restrictionThis data use modifier indicates that use is limited to use within an approved institution.
- GRU DUO:0000042 (version: 2021-02-23)general research useThis data use permission indicates that use is allowed for general research use for any research purpose.
Wellcome Trust Sanger Institute Cancer Genome Group Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| Cancer Genomics |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00000559944 | cram | 319.3 MB | ||
| EGAF00000559945 | cram | 364.2 MB | ||
| EGAF00000559946 | cram | 335.3 MB | ||
| EGAF00000559947 | cram | 374.3 MB | ||
| EGAF00000559948 | cram | 382.6 MB | ||
| EGAF00000559949 | cram | 297.8 MB | ||
| EGAF00000559950 | cram | 508.6 MB | ||
| EGAF00000559951 | cram | 496.9 MB | ||
| EGAF00000559952 | cram | 275.3 MB | ||
| EGAF00000559953 | cram | 357.3 MB | ||
| EGAF00000559954 | cram | 329.2 MB | ||
| EGAF00000559955 | cram | 315.5 MB | ||
| EGAF00000559956 | cram | 515.3 MB | ||
| EGAF00000559957 | cram | 267.9 MB | ||
| EGAF00000559958 | cram | 343.4 MB | ||
| EGAF00000559959 | cram | 341.6 MB | ||
| EGAF00000559960 | cram | 325.0 MB | ||
| EGAF00000559961 | cram | 439.8 MB | ||
| EGAF00000559962 | cram | 352.9 MB | ||
| EGAF00000559963 | cram | 308.9 MB | ||
| EGAF00000559964 | cram | 345.6 MB | ||
| EGAF00000559965 | cram | 368.2 MB | ||
| EGAF00000559966 | cram | 390.8 MB | ||
| EGAF00000559967 | cram | 325.6 MB | ||
| EGAF00000559968 | cram | 244.4 MB | ||
| EGAF00000559969 | cram | 578.8 MB | ||
| EGAF00000559970 | cram | 403.2 MB | ||
| EGAF00000559971 | cram | 373.0 MB | ||
| EGAF00000559972 | cram | 391.8 MB | ||
| EGAF00000559973 | cram | 419.3 MB | ||
| EGAF00000559974 | cram | 454.6 MB | ||
| EGAF00000559975 | cram | 279.0 MB | ||
| EGAF00000559976 | cram | 243.8 MB | ||
| EGAF00000559977 | cram | 414.9 MB | ||
| EGAF00000559978 | cram | 342.3 MB | ||
| EGAF00000559979 | cram | 349.7 MB | ||
| EGAF00000559980 | cram | 337.9 MB | ||
| EGAF00000559981 | cram | 411.4 MB | ||
| EGAF00000559982 | cram | 288.6 MB | ||
| EGAF00000559983 | cram | 357.7 MB | ||
| EGAF00000559984 | cram | 344.7 MB | ||
| EGAF00000559985 | cram | 416.7 MB | ||
| EGAF00000559986 | cram | 214.1 kB | ||
| EGAF00000559987 | cram | 411.1 MB | ||
| EGAF00000559988 | cram | 447.4 MB | ||
| EGAF00000559989 | cram | 313.7 MB | ||
| EGAF00000559990 | cram | 312.4 MB | ||
| EGAF00000559991 | cram | 403.2 MB | ||
| EGAF00000559992 | cram | 437.6 MB | ||
| EGAF00000561985 | cram | 373.4 MB | ||
| EGAF00000561986 | cram | 426.5 MB | ||
| EGAF00000561987 | cram | 393.3 MB | ||
| EGAF00000561988 | cram | 442.7 MB | ||
| EGAF00000561989 | cram | 450.2 MB | ||
| EGAF00000561990 | cram | 349.1 MB | ||
| EGAF00000561991 | cram | 590.5 MB | ||
| EGAF00000561992 | cram | 580.6 MB | ||
| EGAF00000561993 | cram | 321.7 MB | ||
| EGAF00000561994 | cram | 422.5 MB | ||
| EGAF00000561995 | cram | 375.8 MB | ||
| EGAF00000561996 | cram | 372.1 MB | ||
| EGAF00000561997 | cram | 609.4 MB | ||
| EGAF00000561998 | cram | 317.3 MB | ||
| EGAF00000561999 | cram | 405.1 MB | ||
| EGAF00000562000 | cram | 402.5 MB | ||
| EGAF00000562001 | cram | 384.6 MB | ||
| EGAF00000562002 | cram | 522.0 MB | ||
| EGAF00000562003 | cram | 419.9 MB | ||
| EGAF00000562004 | cram | 365.1 MB | ||
| EGAF00000562005 | cram | 407.9 MB | ||
| EGAF00000562006 | cram | 438.2 MB | ||
| EGAF00000562007 | cram | 462.7 MB | ||
| EGAF00000562008 | cram | 385.3 MB | ||
| EGAF00000562009 | cram | 289.1 MB | ||
| EGAF00000562010 | cram | 682.1 MB | ||
| EGAF00000562011 | cram | 477.5 MB | ||
| EGAF00000562012 | cram | 437.3 MB | ||
| EGAF00000562013 | cram | 463.1 MB | ||
| EGAF00000562014 | cram | 499.0 MB | ||
| EGAF00000562015 | cram | 534.5 MB | ||
| EGAF00000562016 | cram | 328.5 MB | ||
| EGAF00000562017 | cram | 288.4 MB | ||
| EGAF00000562018 | cram | 488.3 MB | ||
| EGAF00000562019 | cram | 404.4 MB | ||
| EGAF00000562020 | cram | 409.2 MB | ||
| EGAF00000562021 | cram | 395.9 MB | ||
| EGAF00000562022 | cram | 485.1 MB | ||
| EGAF00000562023 | cram | 337.4 MB | ||
| EGAF00000562024 | cram | 416.5 MB | ||
| EGAF00000562025 | cram | 405.8 MB | ||
| EGAF00000562026 | cram | 491.6 MB | ||
| EGAF00000562027 | cram | 260.0 kB | ||
| EGAF00000562028 | cram | 479.7 MB | ||
| EGAF00000562029 | cram | 521.6 MB | ||
| EGAF00000562030 | cram | 369.1 MB | ||
| EGAF00000562031 | cram | 371.2 MB | ||
| EGAF00000562032 | cram | 477.9 MB | ||
| EGAF00000562033 | cram | 519.6 MB | ||
| EGAF00000562034 | cram | 372.6 MB | ||
| EGAF00000562035 | cram | 425.7 MB | ||
| EGAF00000562036 | cram | 392.2 MB | ||
| EGAF00000562037 | cram | 441.0 MB | ||
| EGAF00000562038 | cram | 448.5 MB | ||
| EGAF00000562039 | cram | 347.5 MB | ||
| EGAF00000562040 | cram | 590.2 MB | ||
| EGAF00000562041 | cram | 578.6 MB | ||
| EGAF00000562042 | cram | 320.5 MB | ||
| EGAF00000562043 | cram | 422.1 MB | ||
| EGAF00000562044 | cram | 374.6 MB | ||
| EGAF00000562045 | cram | 370.6 MB | ||
| EGAF00000562046 | cram | 608.3 MB | ||
| EGAF00000562047 | cram | 316.4 MB | ||
| EGAF00000562048 | cram | 404.4 MB | ||
| EGAF00000562049 | cram | 401.0 MB | ||
| EGAF00000562050 | cram | 383.2 MB | ||
| EGAF00000562051 | cram | 520.5 MB | ||
| EGAF00000562052 | cram | 417.6 MB | ||
| EGAF00000562053 | cram | 364.9 MB | ||
| EGAF00000562054 | cram | 407.3 MB | ||
| EGAF00000562055 | cram | 436.5 MB | ||
| EGAF00000562056 | cram | 460.7 MB | ||
| EGAF00000562057 | cram | 384.0 MB | ||
| EGAF00000562058 | cram | 288.7 MB | ||
| EGAF00000562059 | cram | 680.8 MB | ||
| EGAF00000562060 | cram | 475.9 MB | ||
| EGAF00000562061 | cram | 436.6 MB | ||
| EGAF00000562062 | cram | 461.3 MB | ||
| EGAF00000562063 | cram | 496.9 MB | ||
| EGAF00000562064 | cram | 532.3 MB | ||
| EGAF00000562065 | cram | 327.2 MB | ||
| EGAF00000562066 | cram | 287.6 MB | ||
| EGAF00000562067 | cram | 487.4 MB | ||
| EGAF00000562068 | cram | 402.7 MB | ||
| EGAF00000562069 | cram | 409.0 MB | ||
| EGAF00000562070 | cram | 396.5 MB | ||
| EGAF00000562071 | cram | 483.6 MB | ||
| EGAF00000562072 | cram | 338.3 MB | ||
| EGAF00000562073 | cram | 416.4 MB | ||
| EGAF00000562074 | cram | 404.8 MB | ||
| EGAF00000562075 | cram | 490.9 MB | ||
| EGAF00000562076 | cram | 258.1 kB | ||
| EGAF00000562077 | cram | 479.0 MB | ||
| EGAF00000562078 | cram | 519.2 MB | ||
| EGAF00000562079 | cram | 368.7 MB | ||
| EGAF00000562080 | cram | 370.5 MB | ||
| EGAF00000562081 | cram | 476.8 MB | ||
| EGAF00000562082 | cram | 518.1 MB | ||
| EGAF00001173882 | cram | 1.0 GB | ||
| EGAF00001173883 | cram | 644.4 MB | ||
| EGAF00001173884 | cram | 497.1 MB | ||
| EGAF00001173885 | cram | 745.7 MB | ||
| EGAF00001173886 | cram | 815.3 MB | ||
| EGAF00001173887 | cram | 406.1 MB | ||
| EGAF00001173888 | cram | 706.2 MB | ||
| EGAF00001173889 | cram | 705.1 MB | ||
| EGAF00001173890 | cram | 191.5 MB | ||
| EGAF00001173891 | cram | 316.1 MB | ||
| EGAF00001173892 | cram | 306.6 MB | ||
| EGAF00001173893 | cram | 463.3 MB | ||
| EGAF00001173894 | cram | 465.1 MB | ||
| 160 Files (66.5 GB) | ||||