Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures

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This DAC controls 4 datasets

Dataset ID	Description	Technology	Samples
EGAD00001009491	High coverage whole genome sequencing data (total: 22; median coverage: ~56X; range: 27X – 82X) from fresh frozen postmortem tissues harvested from patients who participated in the CASCADE rapid autopsy program and died of metastatic castration resistant prostate cancer.	Illumina NovaSeq 6000	28
EGAD00001009492	RNA-Seq data from 20 fresh-frozen postmortem samples from three patients who participated in the CASCADE rapid autopsy program and died of metastatic castration resistant prostate cancer.	Illumina NovaSeq 6000	20
EGAD00001009493	High-coverage whole genome sequencing data (median coverage: 23.5X, range: 14.14X-32.62X)) from white blood cells of the patients from isolated buffy coat of the blood drawn postmortem from patients who participated in the CASCADE rapid autopsy program and died of metastatic castration resistant prostate cancer.	Illumina NovaSeq 6000	14
EGAD00001009494	Low-pass whole genome sequencing data (median coverage: 0.37X, range: 0.07X-5.8X) from diagnostic formalin-fixed paraffin-embedded tissue and fresh frozen postmortem tissues from ten organs and postmortem blood from patients who participated in the CASCADE rapid autopsy program and died of metastatic castration resistant prostate cancer. For samples CA27_11, CA34_10, CA35_5, CA35_6, CA36_3, CA36_11, CA63_13, CA63_34, CA76_4, CA76_11, CA79_4, CA83_14 and CA83_26, we subsampled (using `samtools view -s 0.01` after mapping) from respective high coverage data from "CASCADE tumour high-coverage whole genome sequencing data" dataset.	Illumina NovaSeq 6000	152